Academic Journal
Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019
| العنوان: | Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008–2019 |
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| المؤلفون: | Manjate, Filomena, João, Eva D., Chirinda, Percina, Garrine, Marcelino, Vubil, Delfino, Nobela, Nélio, Kotloff, Karen, Nataro, James P., Nhampossa, Tacilta, Acácio, Sozinho, Tate, Jacqueline E., Parashar, Umesh, Mwenda, Jason M., Alonso, Pedro L., Nyaga, Martin, Cunha, Celso, Mandomando, Inácio |
| المساهمون: | Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), TB, HIV and opportunistic diseases and pathogens (THOP) |
| سنة النشر: | 2022 |
| المجموعة: | Repositório da Universidade Nova de Lisboa (UNL) |
| مصطلحات موضوعية: | Case-control study, Genotypes, Mozambique, Rotavirus A, Infectious Diseases, Virology, SDG 3 - Good Health and Well-being, SDG 10 - Reduced Inequalities, SDG 6 - Clean Water and Sanitation, SDG 14 - Life Below Water |
| الوصف: | 870-15 SC; the United States Agency for International Development (USAID), grant number AID-656-F-16-00002 and Fundo Nacional de Investiga??o (FNI), Mo?ambique, grant number 245-INV, within the context of diarrhoeal disease surveillance platform implementation. F.M PhD is supported by Calouste Gulbenkian Foundation, grant number 234066. The authors convey many thanks to all the caregivers who consented to their children?s participation in both studies (GEMS and the diarrhoeal disease platform). They would also like to thank all the professionals in the hospitals and those on field recruitment for their full dedication and effort in children enrolment and collection of data and samples whenever possible. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. ; Group A rotaviruses remain the leading cause of diarrhoea in children aged <5 years. Mozambique introduced rotavirus vaccine (Rotarix® ) in September 2015. We report rotavirus geno-types circulating among symptomatic and asymptomatic children in Manhiça District, Mozambique, pre-and post-vaccine introduction. Stool was collected from enrolled children and screened for ro-tavirus by enzyme-immuno-sorbent assay. Positive specimens were genotyped for VP7 (G genotypes) and VP4 (P genotypes) by the conventional reverse transcriptase polymerase chain reaction. The combination G12P[8] was more frequently observed in pre-vaccine than in post-vaccine introduction, in moderate to severe diarrhoea (34%, 61/177 vs. 0, p < 0.0001) and controls (23%, 26/113 vs. 0, p = 0.0013) and mixed genotypes (36%, 24/67 vs. 7% 4/58, p = 0.0003) in less severe diarrhoea. We observed changes in post-vaccine compared to pre-vaccine introduction, where G3P[4] and G3P[8] were prevalent in moderate to severe diarrhoea (10%, 5/49 vs. 0, p = 0.0002; and 14%, 7/49 vs. 1%, 1/177, p < 0.0001; respectively), and in less severe diarrhoea (21%, 12/58 vs. 0, p = 0.003; and 24%, 14/58 vs. 0, p < 0.0001; respectively). Our surveillance demonstrated the circulation ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-85-12-30164-8 85-12-30164-3 |
| تدمد: | 1999-4915 |
| Relation: | Funding Information: Funding: The GEMS study was funded by the Bill & Melinda Gates Foundation (OPP1033572) through the Center for Vaccine Development, USA. The surveillance of rotavirus and other en-teropathogens in children less than 5 years of age in Manhiça was supported by GAVI through the Centers for Disease Control and Prevention (CDC), Atlanta, and the World Health Organization, Regional Office for Africa (WHO/AFRO), grant number MOA; 870-15 SC; the United States Agency for International Development (USAID), grant number AID-656-F-16-00002 and Fundo Nacional de Investigação (FNI), Moçambique, grant number 245-INV, within the context of diarrhoeal disease surveillance platform implementation. F.M PhD is supported by Calouste Gulbenkian Foundation, grant number 234066. Funding Information: The GEMS study was funded by the Bill & Melinda Gates Foundation (OPP1033572) through the Center for Vaccine Development, USA. The surveillance of rotavirus and other en-teropathogens in children less than 5 years of age in Manhi?a was supported by GAVI through the Centers for Disease Control and Prevention (CDC), Atlanta, and the World Health Organization, Regional Office for Africa (WHO/AFRO), grant number MOA; PURE: 36376352; PURE UUID: 9ec37ee1-e79c-449c-a3a6-55c54737339e; Scopus: 85123016430; ORCID: /0000-0003-4745-3819/work/107026490; http://hdl.handle.net/10362/132538; https://doi.org/10.3390/v14010134 |
| DOI: | 10.3390/v14010134 |
| الاتاحة: | http://hdl.handle.net/10362/132538 https://doi.org/10.3390/v14010134 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.9A46F971 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9788512301648 8512301643 |
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| تدمد: | 19994915 |
| DOI: | 10.3390/v14010134 |