Academic Journal
Maternal oxidative stress during pregnancy associated with emotional and behavioural problems in early childhood: implications for foetal programming
| العنوان: | Maternal oxidative stress during pregnancy associated with emotional and behavioural problems in early childhood: implications for foetal programming |
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| المؤلفون: | Pham, C, Thomson, S, Chin, S-T, Vuillermin, P, O'Hely, M, Burgner, D, Tanner, S, Saffery, R, Mansell, T, Bong, S, Holmes, E, Sly, PD, Gray, N, Ponsonby, A-L, Barwon, ISIG |
| بيانات النشر: | SPRINGERNATURE |
| سنة النشر: | 2023 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Childhood mental disorders, including emotional and behavioural problems (EBP) are increasingly prevalent. Higher maternal oxidative stress (OS) during pregnancy (matOSpreg) is linked to offspring mental disorders. Environmental factors contribute to matOSpreg. However, the role of matOSpreg in childhood EBP is unclear. We investigated the associations between (i) matOSpreg and offspring EBP; (ii) social and prenatal environmental factors and matOSpreg; and (iii) social and prenatal factors and childhood EBP and evaluated whether matOSpreg mediated these associations. Maternal urinary OS biomarkers, 8-hydroxyguanosine (8-OHGua; an oxidative RNA damage marker) and 8-hydroxy-2'-deoxyguanosine (8-OHdG; an oxidative DNA damage marker), at 36 weeks of pregnancy were quantified by liquid chromatography-mass spectrometry in a population-derived birth cohort, Barwon Infant Study (n = 1074 mother-infant pairs). Social and prenatal environmental factors were collected by mother-reported questionnaires. Offspring total EBP was measured by Child Behavior Checklist Total Problems T-scores at age two (n = 675) and Strengths and Difficulties Questionnaire Total Difficulties score at age four (n = 791). Prospective associations were examined by multivariable regression analyses adjusted for covariates. Mediation effects were evaluated using counterfactual-based mediation analysis. Higher maternal urinary 8-OHGua at 36 weeks (mat8-OHGua36w) was associated with greater offspring total EBP at age four (β = 0.38, 95% CI (0.07, 0.69), P = 0.02) and age two (β = 0.62, 95% CI (-0.06, 1.30), P = 0.07). Weaker evidence of association was detected for 8-OHdG. Five early-life factors were associated with both mat8-OHGua36w and childhood EBP (P-range < 0.001-0.05), including lower maternal education, socioeconomic disadvantage and prenatal tobacco smoking. These risk factor-childhood EBP associations were partly mediated by higher mat8-OHGua36w (P-range = 0.01-0.05). Higher matOSpreg, particularly oxidant RNA damage, is associated with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1359-4184 1476-5578 |
| Relation: | NHMRC/1197234; pii: 10.1038/s41380-023-02284-9; Pham, C., Thomson, S., Chin, S. -T., Vuillermin, P., O'Hely, M., Burgner, D., Tanner, S., Saffery, R., Mansell, T., Bong, S., Holmes, E., Sly, P. D., Gray, N., Ponsonby, A. -L. & Barwon, I. S. I. G. (2023). Maternal oxidative stress during pregnancy associated with emotional and behavioural problems in early childhood: implications for foetal programming. MOLECULAR PSYCHIATRY, 28 (9), pp.3760-3768. https://doi.org/10.1038/s41380-023-02284-9.; http://hdl.handle.net/11343/338762 |
| الاتاحة: | http://hdl.handle.net/11343/338762 |
| Rights: | CC BY ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.9A3356FC |
| قاعدة البيانات: | BASE |
| تدمد: | 13594184 14765578 |
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