Academic Journal
Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology
| العنوان: | Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology |
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| المؤلفون: | Rahul S. Patil, McKenzie E. Maloney, Rudolf Lucas, David J. R. Fulton, Vijay Patel, Zsolt Bagi, Anita Kovacs-Kasa, Laszlo Kovacs, Yunchao Su, Alexander D. Verin |
| المصدر: | Biomolecules, Vol 14, Iss 2, p 140 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | lung vascular endothelium, endothelial barrier integrity, zinc-dependent HDACs, deacetylation, HDAC inhibitors, acute lung injury, Microbiology, QR1-502 |
| الوصف: | A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and, as such, provides a semi-selective barrier between the blood and the interstitial space. Compromise of the lung EC barrier due to inflammatory or toxic events may result in pulmonary edema, which is a cardinal feature of acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS). The EC functions are controlled, at least in part, via epigenetic mechanisms mediated by histone deacetylases (HDACs). Zinc-dependent HDACs represent the largest group of HDACs and are activated by Zn 2+ . Members of this HDAC group are involved in epigenetic regulation primarily by modifying the structure of chromatin upon removal of acetyl groups from histones. In addition, they can deacetylate many non-histone histone proteins, including those located in extranuclear compartments. Recently, the therapeutic potential of inhibiting zinc-dependent HDACs for EC barrier preservation has gained momentum. However, the role of specific HDAC subtypes in EC barrier regulation remains largely unknown. This review aims to provide an update on the role of zinc-dependent HDACs in endothelial dysfunction and its related diseases. We will broadly focus on biological contributions, signaling pathways and transcriptional roles of HDACs in endothelial pathobiology associated mainly with lung diseases, and we will discuss the potential of their inhibitors for lung injury prevention. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2218-273X |
| Relation: | https://www.mdpi.com/2218-273X/14/2/140; https://doaj.org/toc/2218-273X; https://doaj.org/article/13389f60a41a4945b12c9ded7ddd2c0f |
| DOI: | 10.3390/biom14020140 |
| الاتاحة: | https://doi.org/10.3390/biom14020140 https://doaj.org/article/13389f60a41a4945b12c9ded7ddd2c0f |
| رقم الانضمام: | edsbas.9A2C64E7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2218273X |
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| DOI: | 10.3390/biom14020140 |