Academic Journal
Awareness and attitude regarding reproductive options of persons carrying a BRCA mutation and their partners
| العنوان: | Awareness and attitude regarding reproductive options of persons carrying a BRCA mutation and their partners |
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| المؤلفون: | Gietel-Habets, J. J. G., de Die-Smulders, C. E. M., Derks-Smeets, I. A. P., Tibben, A., Tjan-Heijnen, V. C. G., van Golde, R., Gomez-Garcia, E., Kets, C. M., van Osch, L. A. D. M. |
| المصدر: | Gietel-Habets , J J G , de Die-Smulders , C E M , Derks-Smeets , I A P , Tibben , A , Tjan-Heijnen , V C G , van Golde , R , Gomez-Garcia , E , Kets , C M & van Osch , L A D M 2017 , ' Awareness and attitude regarding reproductive options of persons carrying a BRCA mutation and their partners ' , Human Reproduction , vol. 32 , no. 3 , pp. 588-597 . https://doi.org/10.1093/humrep/dew352 |
| سنة النشر: | 2017 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Preimplantation genetic diagnosis (PGD), prenatal diagnosis (PND), hereditary breast and ovarian cancer (HBOC), BRCA mutation, awareness, knowledge, acceptability, PREIMPLANTATION GENETIC DIAGNOSIS, OVARIAN-CANCER, HEREDITARY BREAST, DECISION-MAKING, PRENATAL-DIAGNOSIS, BEHAVIOR-CHANGE, CARRIERS, METAANALYSIS, PERCEPTIONS, CHALLENGE |
| الوصف: | STUDY QUESTION: To what extent are BRCA mutation carriers and their partners in the Netherlands aware about preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND) as reproductive options and what is their attitude towards these options? SUMMARY ANSWER: Awareness of PGD (66%) and PND (61%) among BRCA mutation carriers and their partners is relatively high and 80% and 26%, respectively, of BRCA carriers and their partners find offering PGD and PND for hereditary breast and ovarian cancer (HBOC) acceptable. WHAT IS KNOWN ALREADY: Internationally, awareness of PGD among persons with a genetic cancer predisposition appears to be relatively low (35%) and although acceptability is generally high (71%), only a small proportion of mutation carriers would consider using PGD (36%). However, for HBOC, there are no studies available that investigated the perspective of individuals with a confirmed BRCA1/2 mutation and their partners about PGD and PND including demographic and medical correlates of awareness and acceptability. STUDY DESIGN, SIZE, DURATION: A cross-sectional survey was completed by 191 participants between July 2012 and June 2013. Participants were recruited through patient organizations (88%) and the databases of two Clinical Genetics departments in the Netherlands (12%). PARTICIPANTS/MATERIALS, SETTING, METHODS: Male and female BRCA carriers and their partners completed an online survey, which assessed demographic and medical characteristics, and awareness, knowledge, acceptability and consideration of PGD and PND as main outcomes. Correlations between demographic and medical characteristics and the main outcomes were investigated. MAIN RESULTS AND ROLE OF CHANCE: The majority of respondents were female (87%), of reproductive age (86%) and about half reported a desire for a child in the future. About two-thirds (66%) were aware of PGD and 61% of PND for HBOC. PGD knowledge was moderate (5.5 on a 9-point scale) and acceptability of PGD and PND for HBOC was 80% and 26%, respectively. A minority ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/humrep/dew352 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/d92477ab-6ac3-4662-bf1a-465d4de5f135 https://doi.org/10.1093/humrep/dew352 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9A049659 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/humrep/dew352 |
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