التفاصيل البيبلوغرافية
| العنوان: |
Metformin and Breast Cancer: Where Are We Now? |
| المؤلفون: |
Cejuela, Mónica, Martin Castillo, Begoña, Menendez, Javier A., Pernas, Sònia |
| المصدر: |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| بيانات النشر: |
MDPI AG |
| سنة النشر: |
2022 |
| المجموعة: |
Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: |
Càncer de mama, Diabetis, Breast cancer, Diabetes |
| الوصف: |
Breast cancer is the most prevalent cancer and the leading cause of cancer-related death among women worldwide. Type 2 diabetes-associated metabolic traits such as hyperglycemia, hyperinsulinemia, inflammation, oxidative stress, and obesity are well-known risk factors for breast cancer. The insulin sensitizer metformin, one of the most prescribed oral antidiabetic drugs, has been suggested to function as an antitumoral agent, based on epidemiological and retrospective clinical data as well as preclinical studies showing an antiproliferative effect in cultured breast cancer cells and animal models. These benefits provided a strong rationale to study the effects of metformin in routine clinical care of breast cancer patients. However, the initial enthusiasm was tempered after disappointing results in randomized controlled trials, particularly in the metastatic setting. Here, we revisit the current state of the art of metformin mechanisms of action, critically review past and current metformin-based clinical trials, and briefly discuss future perspectives on how to incorporate metformin into the oncologist's armamentarium for the prevention and treatment of breast cancer. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
19 p.; application/pdf |
| اللغة: |
English |
| تدمد: |
1422-0067 |
| Relation: |
Reproducció del document publicat a: https://doi.org/10.3390/ijms23052705; International Journal of Molecular Sciences, 2022, vol. 23, num. 5; https://doi.org/10.3390/ijms23052705; http://hdl.handle.net/2445/184622 |
| الاتاحة: |
http://hdl.handle.net/2445/184622 |
| Rights: |
cc by (c) Cejuela, Mónica et al, 2022 ; http://creativecommons.org/licenses/by/3.0/es/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.99F4774D |
| قاعدة البيانات: |
BASE |
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