Academic Journal
Targeting mTOR signaling for the treatment of intrahepatic cholangiocarcinoma with TSC1/ARID1A mutations: a case report with an unexpected response
| العنوان: | Targeting mTOR signaling for the treatment of intrahepatic cholangiocarcinoma with TSC1/ARID1A mutations: a case report with an unexpected response |
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| المؤلفون: | Clémentine Daugan, Romain Boidot, François Ghiringhelli, Christophe Borg, Angélique Vienot |
| المصدر: | Therapeutic Advances in Medical Oncology, Vol 16 (2024) |
| بيانات النشر: | SAGE Publishing |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Biliary tract cancer incidence is increasing and the prognostic remains dismal. The development of personalized medicine is a pivotal issue in proposing therapeutic options for biliary tract cancer patients. Whole exome sequencing identifies approximately 15% of IDH1 mutations and 15% of FGFR2 fusions in intrahepatic cholangiocarcinoma. Other patients are not currently eligible for targeted therapy. Here, we present a patient treated for a metastatic cholangiocarcinoma with an unexpected response to a mammalian target of rapamycin (mTOR) targeting agent. Whole exome sequencing enabled the identification of TSC1 and ARID1A mutations. Reintroduction of mTOR inhibitors with similar results sustains the main role of these targeted agents in the control of the disease. These results suggest the existence of an mTOR oncogenic addiction in biliary tract cancer. Our results support the interest in performing exome sequencing in liver cancers and the potential to identify actionable mutations with important therapeutic issues. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1758-8359 |
| Relation: | https://doi.org/10.1177/17588359241271793; https://doaj.org/toc/1758-8359; https://doaj.org/article/51c99f82ed53476c90515933212ae6e6 |
| DOI: | 10.1177/17588359241271793 |
| الاتاحة: | https://doi.org/10.1177/17588359241271793 https://doaj.org/article/51c99f82ed53476c90515933212ae6e6 |
| رقم الانضمام: | edsbas.99CD0815 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17588359 |
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| DOI: | 10.1177/17588359241271793 |