Academic Journal
Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure
| العنوان: | Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure |
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| المؤلفون: | Stubnova, Viera, Os, Ingrid, Høieggen, Aud, Solbu, Marit Dahl, Grundtvig, Morten, Westheim, Arne, Atar, Dan, Waldum-Grevbo, Bård |
| بيانات النشر: | BMC |
| سنة النشر: | 2019 |
| المجموعة: | University of Tromsø: Munin Open Research Archive |
| مصطلحات موضوعية: | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771, Uric acid, Heart failure, Gender, Kidney disease, All-cause mortality, Propensity score, Epidemiology |
| الوصف: | Source at https://doi.org/10.1186/s12872-018-0989-8 . ; Background - Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure (HF) outpatients. Furthermore, to assess whether gender or renal function modified the effect of SUA. Methods - Patients ( n = 4684) from the Norwegian Heart Failure Registry with baseline SUA were included in the study. Individuals in the highest gender-specific SUA quartile were propensity score matched 1:1 with patients in the lowest three SUA quartiles. The propensity score matching procedure created 928 pairs of patients (73.4% males, mean age 71.4 ± 11.5 years) with comparable baseline characteristics. Kaplan Meier and Cox regression analyses were used to investigate the independent effect of SUA on all-cause mortality. Results - SUA in the highest quartile was an independent predictor of all-cause mortality in HF outpatients (hazard ratio (HR) 1.19, 95% confidence interval (CI) 1.03–1.37, p -value 0.021). Gender was found to interact the relationship between SUA and all-cause mortality ( p -value for interaction 0.007). High SUA was an independent predictor of all-cause mortality in women (HR 1.65, 95% CI 1.24–2.20, p -value 0.001), but not in men (HR 1.06, 95% CI 0.89–1.25, p -value 0.527). Renal function did not influence the relationship between SUA and all-cause mortality ( p -value for interaction 0.539). Conclusions - High SUA was independently associated with inferior 5-year survival in Norwegian HF outpatients. The finding was modified by gender and high SUA was only an independent predictor of 5-year all-cause mortality in women, not in men. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2261 |
| Relation: | BMC Cardiovascular Disorders; Stubnova, V., Os, I., Høieggen, A., Solbu, M.D., Grundtvig, M., Westheim, A.S., Atar, D. & Waldum-Grevbo, B. (2019). Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure. BMC Cardiovascular Disorders, 19 , 4. https://doi.org/10.1186/s12872-018-0989-8; FRIDAID 1658655; https://hdl.handle.net/10037/16328 |
| DOI: | 10.1186/s12872-018-0989-8 |
| الاتاحة: | https://hdl.handle.net/10037/16328 https://doi.org/10.1186/s12872-018-0989-8 |
| Rights: | openAccess |
| رقم الانضمام: | edsbas.99AA2951 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712261 |
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| DOI: | 10.1186/s12872-018-0989-8 |