Academic Journal

Time to Mammographic Density Decrease After Exposure to Tamoxifen

التفاصيل البيبلوغرافية
العنوان: Time to Mammographic Density Decrease After Exposure to Tamoxifen
المؤلفون: Bäcklund, Magnus, Eriksson, Mikael, Hammarström, Mattias, Thoren, Linda, Bergqvist, Jenny, Margolin, Sara, Hellgren, Roxanna, Wengström, Yvonne, Gabrielson, Marike, Czene, Kamila, Hall, Per
المصدر: The Oncologist ; volume 27, issue 7, page e601-e603 ; ISSN 1083-7159 1549-490X
بيانات النشر: Oxford University Press (OUP)
سنة النشر: 2022
الوصف: Mammographic density change has proven to be a reliable proxy for tamoxifen therapy response. The primary aim of this study was to identify time to tamoxifen-induced mammographic density change. We also analyzed side effects and adherence to therapy. In all, 42 women were randomized to 10 or 20 mg of daily oral tamoxifen. Mammograms were taken at baseline, 3, 6, and 9 months. Mammographic density change was measured using the automated STRATUS tool. Adverse events were monitored through a web-based questionnaire based on the FACT-ES tool. Nine out of the 42 (21%) participants discontinued therapy due to adverse events leaving 33 women in the study. A significant decrease in density was seen after 3 months of therapy. Dose did not seem to affect density change, side effects or adherence. Given the size of the study, additional studies are needed to confirm our data.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1093/oncolo/oyac104
الاتاحة: http://dx.doi.org/10.1093/oncolo/oyac104
https://academic.oup.com/oncolo/article-pdf/27/7/e601/44418310/oyac104.pdf
Rights: https://creativecommons.org/licenses/by-nc/4.0/
رقم الانضمام: edsbas.99A3BE82
قاعدة البيانات: BASE