Academic Journal
Release of Bioactive Molecules from Graphene Oxide-Alginate Hybrid Hydrogels: Effect of Crosslinking Method
| العنوان: | Release of Bioactive Molecules from Graphene Oxide-Alginate Hybrid Hydrogels: Effect of Crosslinking Method |
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| المؤلفون: | Madeo, Lorenzo Francesco, Curcio, Manuela, Iemma, Francesca, Nicoletta, Fiore Pasquale, Hampel, Silke, Cirillo, Giuseppe |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | ddc:570, ddc:610, crosslinking methods, electro-responsivity, graphene oxide, hybrid hydrogels, sodium alginate, sustained release |
| الوصف: | To investigate the influence of crosslinking methods on the releasing performance of hybrid hydrogels, we synthesized two systems consisting of Graphene oxide (GO) as a functional element and alginate as polymer counterpart by means of ionic gelation (physical method, 𝐻𝑃𝐴−𝐺𝑂) and radical polymerization (chemical method, 𝐻𝐶𝐴−𝐺𝑂). Formulations were optimized to maximize the GO content (2.0 and 1.15% for 𝐻𝑃𝐴−𝐺𝑂 and 𝐻𝐶𝐴−𝐺𝑂, respectively) and Curcumin (CUR) was loaded as a model drug at 2.5, 5.0, and 7.5% (by weight). The physico-chemical characterization confirmed the homogeneous incorporation of GO within the polymer network and the enhanced thermal stability of hybrid vs. blank hydrogels. The determination of swelling profiles showed a higher swelling degree for 𝐻𝐶𝐴−𝐺𝑂 and a marked pH responsivity due to the COOH functionalities. Moreover, the application of external voltages modified the water affinity of 𝐻𝐶𝐴−𝐺𝑂, while they accelerated the degradation of 𝐻𝑃𝐴−𝐺𝑂 due to the disruption of the crosslinking points and the partial dissolution of alginate. The evaluation of release profiles, extensively analysed by the application of semi-empirical mathematical models, showed a sustained release from hybrid hydrogels, and the possibility to modulate the releasing amount and rate by electro-stimulation of 𝐻𝐶𝐴−𝐺𝑂. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | ESSN:2311-5629; https://oa.tib.eu/renate/handle/123456789/12462; https://doi.org/10.34657/11492 |
| DOI: | 10.34657/11492 |
| الاتاحة: | https://oa.tib.eu/renate/handle/123456789/12462 https://doi.org/10.34657/11492 |
| Rights: | CC BY 4.0 Unported ; https://creativecommons.org/licenses/by/4.0/ ; frei zugänglich |
| رقم الانضمام: | edsbas.99878890 |
| قاعدة البيانات: | BASE |
| DOI: | 10.34657/11492 |
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