Academic Journal
Changes in cerebral oxygenation and cerebral blood flow during hemodialysis – A simultaneous near-infrared spectroscopy and positron emission tomography study
| العنوان: | Changes in cerebral oxygenation and cerebral blood flow during hemodialysis – A simultaneous near-infrared spectroscopy and positron emission tomography study |
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| المؤلفون: | Polinder-Bos, Harmke A., Elting, Jan Willem J., Aries, Marcel J.H., Vállez García, David, Willemsen, Antoon T.M., van Laar, Peter J., Kuipers, Johanna, Krijnen, Wim P., Slart, Riemer H.J.A., Luurtsema, Gert, Westerhuis, Ralf, Gansevoort, Ron T., Gaillard, Carlo A.J.M., Franssen, Casper F.M. |
| المصدر: | Polinder-Bos , H A , Elting , J W J , Aries , M J H , Vállez García , D , Willemsen , A T M , van Laar , P J , Kuipers , J , Krijnen , W P , Slart , R H J A , Luurtsema , G , Westerhuis , R , Gansevoort , R T , Gaillard , C A J M & Franssen , C F M 2020 , ' Changes in cerebral oxygenation and cerebral blood flow during hemodialysis – A simultaneous near-infrared spectroscopy and positron emission tomography study ' .... |
| سنة النشر: | 2020 |
| الوصف: | Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO 2 ) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [ 15 O]H 2 O positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO 2 and CBF. In 12 patients aged ≥ 65 years, NIRS and PET were performed simultaneously: before (T1), early after start (T2), and at the end of hemodialysis (T3). Between T1 and T3, the relative change in frontal rSO 2 (ΔrSO 2 ) was −8 ± 9% (P = 0.001) and −5 ± 11% (P = 0.08), whereas the relative change in frontal gray matter CBF (ΔCBF) was −11 ± 18% (P = 0.009) and −12 ± 16% (P = 0.007) for the left and right hemisphere, respectively. ΔrSO 2 and ΔCBF were weakly correlated for the left (ρ 0.31, P = 0.4), and moderately correlated for the right (ρ 0.69, P = 0.03) hemisphere. The Bland-Altman plot suggested underestimation of ΔCBF by NIRS. Divergent associations of pH, pCO 2 and arterial oxygen content with rSO 2 were found compared to corresponding associations with CBF. In conclusion, NIRS could be a proxy to PET to detect intradialytic CBF changes, although NIRS and PET capture different physiological parameters of the brain. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/0271678X18818652 |
| الاتاحة: | https://research.vumc.nl/en/publications/578a0b63-b8a0-4849-b527-e77a715e188d https://doi.org/10.1177/0271678X18818652 http://www.scopus.com/inward/record.url?scp=85060516081&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.996DD8B5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0271678X18818652 |
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