Academic Journal
The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues
| العنوان: | The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues |
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| المؤلفون: | Rösler A, Panayotou G, Hornby DP, Barlow T, Brown T, Pearl LH, Savva, Renos, Blackburn GM |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2000 |
| المجموعة: | Birkbeck University of London: BIROn - Birkbeck Institutional Research Online |
| مصطلحات موضوعية: | Biological Sciences |
| الوصف: | 2′,4′-Dideoxy-4′-methyleneuridine incorporated into oligodeoxynucleotides forms regular B-DNA duplexes as shown by Tm and CD measurements. Such oligomers are not cleaved by the DNA repair enzyme, UDG, which cleaves the glycosylic bond in dU but not in dT nor in dC nucleosides in single stranded and double stranded DNA. Differential binding of oligomers containing carbadU, 4′-thiodU, and dU residues to wild type and mutant UDG proteins identify an essential role for the furanose 4′-oxygen in recognition and cleavage of dU residues in DNA. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | Rösler A and Panayotou G and Hornby DP and Barlow T and Brown T and Pearl LH and Savva, Renos and Blackburn GM (2000) The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues. Nucleosides, Nucleotides and Nucleic Acids 19 (10-12), pp. 1505-1516. ISSN 1525-7770. |
| DOI: | 10.1080/15257770008045442 |
| الاتاحة: | https://eprints.bbk.ac.uk/id/eprint/27522/ https://doi.org/10.1080/15257770008045442 |
| رقم الانضمام: | edsbas.991FF61D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/15257770008045442 |
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