Academic Journal
Molecular Imaging of Invasive Pulmonary Aspergillosis using ImmunoPET/MRI: The Future Looks Bright
| العنوان: | Molecular Imaging of Invasive Pulmonary Aspergillosis using ImmunoPET/MRI: The Future Looks Bright |
|---|---|
| المؤلفون: | Thornton, CR |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2018 |
| المجموعة: | University of Exeter: Open Research Exeter (ORE) |
| مصطلحات موضوعية: | Monoclonal antibody (mAb), Invasive Pulmonary Aspergillosis, Positron-Emission Tomography, Magnetic Resonance Imaging, immunoPET-MRI |
| الوصف: | This is the final version of the article. Available from Frontiers Media via the DOI in this record. ; Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of immuno-compromised humans caused by the ubiquitous environmental mould Aspergillus. Biomarker tests for the disease lack sensitivity and specificity, and culture of the fungus from invasive lung biopsy is slow, insensitive, and undesirable in critically ill patients. A Computed Tomogram (CT) of the chest offers a simple non-intrusive diagnostic procedure for rapid decision-making, and so is used in many haematology units to drive antifungal treatment. However, radiological indicators that raise the suspicion of IPA are either transient signs in the early stages of the disease, or are not specific for Aspergillus infection, with other angio-invasive moulds or bacterial pathogens producing comparable radiological manifestations in a chest CT. Improvements to the specificity of radiographic imaging of IPA have been attempted by coupling CT and Positron Emission Tomography (PET) with [18F]FDG, a marker of metabolic activity well-suited to cancer imaging, but with limited use in invasive fungal disease diagnostics due to its inability to differentiate between infectious etiologies, cancer, and inflammation. Bioluminescence imaging using single genetically modified strains of Aspergillus fumigatus has enabled in vivo monitoring of IPA in animal models of disease. For in vivo detection of Aspergillus lung infections in humans, radiolabelled Aspergillus-specific monoclonal antibodies, and iron siderophores, hold enormous potential for clinical diagnosis. This review examines the different experimental technologies used to image IPA, and recent advances in state-of-the-art molecular imaging of IPA using antibody-guided Positron Emission Tomography/Magnetic Resonance Imaging (immunoPET/MRI). ; This work was supported by the European Union Seventh Framework Program FP7/2007-2013 under grant 602820. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Online: 09 April 2018; http://hdl.handle.net/10871/32371; Frontiers in Microbiology |
| DOI: | 10.3389/fmicb.2018.00691 |
| الاتاحة: | http://hdl.handle.net/10871/32371 https://doi.org/10.3389/fmicb.2018.00691 |
| Rights: | Copyright © 2018 Thornton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| رقم الانضمام: | edsbas.98A6BAA6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fmicb.2018.00691 |
|---|