Academic Journal
Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?
| العنوان: | Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems? |
|---|---|
| المؤلفون: | T Tissot, Beata Ujvari, E Solary, P Lassus, B Roche, F Thomas |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Oncology and carcinogenesis not elsewhere classified, Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Biophysics, Oncology, Evolution, Ecology, Non-cell-autonomous effects, Mutations, Cancer, EVOLUTIONARY GAME-THEORY, CANCER STEM-CELLS, PUBLIC-GOODS, CLONAL EVOLUTION, DRUG-RESISTANCE, INTRATUMOR HETEROGENEITY, PASSENGER MUTATIONS, STROMAL CELLS, GROWTH, ANGIOGENESIS, 111201 Cancer Cell Biology, 060103 Cell Development, Proliferation and Death, 970106 Expanding Knowledge in the Biological Sciences, Centre for Integrative Ecology, School of Life and Environmental Sciences, 3101 Biochemistry and cell biology |
| الوصف: | By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | http://hdl.handle.net/10536/DRO/DU:30085158 |
| الاتاحة: | http://hdl.handle.net/10536/DRO/DU:30085158 https://figshare.com/articles/journal_contribution/Do_cell-autonomous_and_non-cell-autonomous_effects_drive_the_structure_of_tumor_ecosystems_/20889862 |
| Rights: | All Rights Reserved |
| رقم الانضمام: | edsbas.989E2545 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |