Academic Journal
Segmental colonic dilation is associated with premature termination of high‐amplitude propagating contractions in children with intractable functional constipation
| العنوان: | Segmental colonic dilation is associated with premature termination of high‐amplitude propagating contractions in children with intractable functional constipation |
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| المؤلفون: | Koppen, I. J. N., Thompson, B. P., Ambeba, E. J., Lane, V. A., Bates, D. G., Minneci, P. C., Deans, K. J., Levitt, M. A., Wood, R. J., Benninga, M. A., Di Lorenzo, C., Yacob, D. |
| المساهمون: | The Royal Netherlands Academy of Arts and Sciences (Academy Ter Meulen Grant), European Society for Pediatric Gastroenterology, Hepatology and Nutrition (Charlotte Anderson Travel Award) |
| المصدر: | Neurogastroenterology & Motility ; volume 29, issue 10, page 1-9 ; ISSN 1350-1925 1365-2982 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2017 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Colonic dilation is common in children with intractable functional constipation ( FC ). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC . Methods We performed a retrospective study on 30 children with intractable FC (according to the Rome III criteria) who had undergone colonic manometry and contrast enema within a 12‐month time period. Colonic diameter was measured at 5 cm intervals from the anal verge up to the splenic flexure. Moreover, the distance between the lateral margins of the pedicles of vertebra L2 was measured to provide a ratio (colonic diameter or length/distance between the lateral margins; “standardized colon size” [ SCS ]). All manometry recordings were visually inspected for the presence of high‐amplitude propagating contractions ( HAPC s); a parameter for colonic motility integrity. The intracolonic location of the manometry catheter sensors was assessed using an abdominal X‐ray. Key Results Colonic segments with HAPC s had a significantly smaller median diameter than colonic segments without HAPC s (4.08 cm vs 5.48 cm, P <.001; SCS 1.14 vs 1.66, P =.001). Children with prematurely terminating HAPC s had significantly larger SCS ratios for colonic diameter than children with fully propagating HAPC s ( P =.008). SCS ratios for the length of the rectosigmoid and the descending colon and the SCS ratio for sigmoid colon diameter were significantly larger in children with FC compared to a previously described normative population ( P <.0001, P <.0001 and P =.0007 respectively). Conclusions & Inferences Segmental colonic dilation was associated with prematurely terminating HAPC s and may be a useful indicator of colonic dysmotility. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/nmo.13110 |
| الاتاحة: | http://dx.doi.org/10.1111/nmo.13110 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fnmo.13110 https://onlinelibrary.wiley.com/doi/pdf/10.1111/nmo.13110 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.987397B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/nmo.13110 |
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