Academic Journal
Postacute sequelae of COVID-19 pneumonia: 6-month chest CT follow-up
| العنوان: | Postacute sequelae of COVID-19 pneumonia: 6-month chest CT follow-up |
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| المؤلفون: | Caruso D, Guido G, Zerunian M, Polidori T, Lucertini E, Pucciarelli F, Polici M, Rucci C, Bracci B, Nicolai M, Cremona A, De Dominicis C, Laghi A |
| المساهمون: | Caruso, D, Guido, G, Zerunian, M, Polidori, T, Lucertini, E, Pucciarelli, F, Polici, M, Rucci, C, Bracci, B, Nicolai, M, Cremona, A, De Dominicis, C, Laghi, A |
| سنة النشر: | 2021 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | COVID-19, CT, quantitative chest computed tomography, lung severity Score, follow-up |
| الوصف: | Background The long-term post acute pulmonary sequelae of COVID-19 remain unknown. Purpose To evaluate lung injury in patients affected by COVID-19 pneumonia at six-month follow-up compared to baseline chest CT. Methods From March 19th,2020 to May 24th,2020, patients with moderate to severe COVID-19 pneumonia and baseline Chest CT were prospectively enrolled at six-months follow-up. CT qualitative findings, semi- quantitative Lungs Severity Score (LSS) and well-aerated lung quantitative Chest CT (QCCT) were analyzed. Baseline LSS and QCCT performances in predicting fibrotic-like changes (reticular pattern and/or honeycombing) at six-month follow-up Chest CT were tested with receiver operating characteristic curves. Univariable and multivariable logistic regression analysis were used to test clinical and radiological features predictive of fibrotic-like changes. The multivariable analysis was performed with clinical parameters alone (clinical model), radiological parameters alone (radiological model) and the combination of clinical and radiological parameters (combined model). Results One-hundred-eighteen patients, with both baseline and six-month follow-up Chest CT, were included in the study (62 female, mean age 65±12 years). At follow-up Chest CT, 85/118 (72%) patients showed fibrotic-like changes and 49/118 (42%) showed GGOs. Baseline LSS (>14), QCCT (≤3.75L and ≤80%) showed an excellent performance in predicting fibrotic-like changes at Chest CT follow-up. In the multivariable analysis, AUC was .89 (95%CI .77-.96) for the clinical model, .81 (95%CI .68-.9) for the radiological model and .92 (95%CI .81- .98)for the combined model. Conclusion At six-month follow-up Chest CT, 72% of patients showed late sequelae, in particular fibrotic-like changes. Baseline LSS and QCCT of well-aerated lung showed an excellent performance in predicting fibrotic-like changes at six-month Chest CT (AUC>.88). Male sex, cough, lymphocytosis and QCCT well-aerated lung were significant predictors of fibrotic-like changes at ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34313468; info:eu-repo/semantics/altIdentifier/wos/WOS:000710995100028; volume:301; issue:2; journal:RADIOLOGY; http://hdl.handle.net/11573/1580775; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118187919 |
| DOI: | 10.1148/radiol.2021210834 |
| الاتاحة: | http://hdl.handle.net/11573/1580775 https://doi.org/10.1148/radiol.2021210834 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.98556D9F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1148/radiol.2021210834 |
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