Academic Journal
An Updated Examination of the Perception of Barriers for Pharmacogenomics Implementation and the Usefulness of Drug/Gene Pairs in Latin America and the Caribbean
| العنوان: | An Updated Examination of the Perception of Barriers for Pharmacogenomics Implementation and the Usefulness of Drug/Gene Pairs in Latin America and the Caribbean |
|---|---|
| المؤلفون: | Salas-Hernández, Aimeé, Galleguillos, Macarena, Carrasco, MatÃas, López-Cortés, Andrés, Redal, MarÃa Ana, Fonseca-Mendoza, Dora, Esperón, Patricia, González-MartÃnez, Farith, Lares-Asseff, Ismael, Lazarowski, Alberto, Loera-Castañeda, Verónica, RemÃrez, Diadelis, MartÃnez, MatÃas F, Vargas, Rodrigo, Rios-Santos, Fabricio, Macho, Antonio, Cayún, Juan P, Perez, Germán R, Gutierrez, Carolina, Cerpa, Leslie C, Leiva, Tamara, Calfunao, Susan, Xajil, Lesly, Sandoval, Christopher, Suárez, Marcelo, Gonzalez, Ariana, EcheverrÃa-Garcés, Gabriela, Sullón-Dextre, Luis, Cordero-GarcÃa, Eugenia, Morales, Alexis R, Avendaño, Andrea, Sánchez, Enrique, Bastone, Laura C, Lara, Cesar, Zuluaga-Arias, Patricia, Soler, Ana MarÃa, Da Luz, Julio, Burgueño-RodrÃguez, Gabriela, Vital, Marcelo, Reyes-Reyes, Elizabeth, Huaccha, Alexander, Ariza, Yeimy V, Tzul, Naomi, Rendón, Ana L, Serrano, Roberto, Acosta, Larissa, Motta-Pardo, Angelo, Beltrán-Angarita, Leonardo, Brand, Erika, Jiménez, Miguel A, Hidalgo-Lozada, Gladys Maribel, Romero-Prado, Marina M J, Escobar-Castro, Karla, Umaña-Rivas, Mariel, Vivas, Juan D, Lagos, Paola, MartÃnez, Yineth Ballén, Quesada, Sharleth, Calfio, Camila, Arias, Maria L, Lavanderos, MarÃa A, Cáceres, Dante D, Salazar-Granara, Alberto, Varela, Nelson M, Quiñones, Luis A |
| المصدر: | Journal Articles |
| بيانات النشر: | DigitalCommons@TMC |
| سنة النشر: | 2023 |
| المجموعة: | Houston Academy of Medicine-Texas Medical Center (HAM-TMC): DigitalCommons@The Texas Medical Center |
| مصطلحات موضوعية: | pharmacogenetics, pharmacogenomics, gene/drug pair, barriers, precision medicine, Medical Genetics, Medical Sciences, Medical Specialties, Medicinal and Pharmaceutical Chemistry, Medicine and Health Sciences, Pharmacy and Pharmaceutical Sciences, Race and Ethnicity, Social and Behavioral Sciences, Sociology |
| الوصف: | Pharmacogenomics (PGx) is considered an emergent field in developing countries. Research on PGx in the Latin American and the Caribbean (LAC) region remains scarce, with limited information in some populations. Thus, extrapolations are complicated, especially in mixed populations. In this paper, we reviewed and analyzed pharmacogenomic knowledge among the LAC scientific and clinical community and examined barriers to clinical application. We performed a search for publications and clinical trials in the field worldwide and evaluated the contribution of LAC. Next, we conducted a regional structured survey that evaluated a list of 14 potential barriers to the clinical implementation of biomarkers based on their importance. In addition, a paired list of 54 genes/drugs was analyzed to determine an association between biomarkers and response to genomic medicine. This survey was compared to a previous survey performed in 2014 to assess progress in the region. The search results indicated that Latin American and Caribbean countries have contributed 3.44% of the total publications and 2.45% of the PGx-related clinical trials worldwide thus far. A total of 106 professionals from 17 countries answered the survey. Six major groups of barriers were identified. Despite the region’s continuous efforts in the last decade, the primary barrier to PGx implementation in LAC remains the same, the “need for guidelines, processes, and protocols for the clinical application of pharmacogenetics/pharmacogenomicsâ€. Cost-effectiveness issues are considered critical factors in the region. Items related to the reluctance of clinicians are currently less relevant. Based on the survey results, the highest ranked (96%–99%) gene/drug pairs perceived as important were CYP2D6/tamoxifen, CYP3A5/tacrolimus, CYP2D6/opioids, DPYD/fluoropyrimidines, TMPT/thiopurines, CYP2D6/tricyclic antidepressants, CYP2C19/tricyclic antidepressants, NUDT15/thiopurines, CYP2B6/efavirenz, and CYP2C19/clopidogrel. In conclusion, although the global contribution ... |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://digitalcommons.library.tmc.edu/uthmed_docs/2375; https://digitalcommons.library.tmc.edu/context/uthmed_docs/article/3332/viewcontent/fphar_14_1175737.pdf |
| الاتاحة: | https://digitalcommons.library.tmc.edu/uthmed_docs/2375 https://digitalcommons.library.tmc.edu/context/uthmed_docs/article/3332/viewcontent/fphar_14_1175737.pdf |
| رقم الانضمام: | edsbas.983A76EB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |