Academic Journal
Memory Modulation by Weak Synchronous Deep Brain Stimulation: A Pilot Study
| العنوان: | Memory Modulation by Weak Synchronous Deep Brain Stimulation: A Pilot Study |
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| المؤلفون: | Juergen Fell, Bernhard P. Staresina, Anne T.A. Do Lam, Guido Widman, Christoph Helmstaedter, Christian E. Elger, Nikolai Axmacher |
| المصدر: | Brain Stimulation, Vol 6, Iss 3, Pp 270-273 (2013) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Declarative memory, Hippocampus, Rhinal cortex, Synchronization, DBS, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Zero-lag phase synchronization of EEG activity has been reported to be a central mechanism accompanying long-term memory formation. In this pilot study, we examined the effects of synchronous low-amplitude stimulation of the rhinal cortex and the hippocampus in eleven temporal lobe epilepsy patients. The impact of in-phase stimulation (zero lag) on long-term memory encoding of words was contrasted with anti-phase (180° phase lag) and sham stimulation. We hypothesized more correctly remembered words for the in-phase compared to the sham condition and fewer correctly remembered words for the anti-phase vs. the sham condition. Indeed, we observed a trend for a linear condition effect for correctly remembered words, which is in accordance to our prediction (in-phase > sham > anti-phase). This finding suggests that even weak synchronous deep brain stimulation of rhinal cortex and hippocampus may modulate memory performance, while clear evidence for an enhancement of memory by this kind of deep brain simulation is still lacking. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1935-861X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1935861X12001490; https://doaj.org/toc/1935-861X; https://doaj.org/article/6af3bbf359ef4898aed0641ad668f028 |
| DOI: | 10.1016/j.brs.2012.08.001 |
| الاتاحة: | https://doi.org/10.1016/j.brs.2012.08.001 https://doaj.org/article/6af3bbf359ef4898aed0641ad668f028 |
| رقم الانضمام: | edsbas.9805C8B |
| قاعدة البيانات: | BASE |
| تدمد: | 1935861X |
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| DOI: | 10.1016/j.brs.2012.08.001 |