Academic Journal
Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia
| العنوان: | Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia |
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| المؤلفون: | van Hal, S.J., Espedido, B.A., Coombs, G.W., Howden, B.P., Korman, T.M., Nimmo, G.R., Gosbell, I.B., Jensen, S.O. |
| بيانات النشر: | Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy |
| سنة النشر: | 2017 |
| الوصف: | Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| تدمد: | 0305-7453 |
| Relation: | ispartof: Journal of Antimicrobial Chemotherapy spage 998 epage 1001 issue 4 vol 72; WOS:000402070800007; http://dx.doi.org/10.1093/jac/dkw539; 991005543645407891; https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Polyclonal-emergence-of-vanA-vancomycin-resistant-Enterococcus/991005543645407891; https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12136125950007891/13136862970007891; alma:61MUN_INST/bibs/991005543645407891 |
| DOI: | 10.1093/jac/dkw539 |
| الاتاحة: | https://doi.org/10.1093/jac/dkw539 https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Polyclonal-emergence-of-vanA-vancomycin-resistant-Enterococcus/991005543645407891 https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12136125950007891/13136862970007891 |
| Rights: | © The Author 2016 ; Open |
| رقم الانضمام: | edsbas.97FB789B |
| قاعدة البيانات: | BASE |
| تدمد: | 03057453 |
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| DOI: | 10.1093/jac/dkw539 |