Academic Journal
Resolution patterns and duration of retinal haemorrhages measured by two-dimensional retinal area pixel counts from sequential retinal imaging in childhood encephalopathies: a morphometric study
| العنوان: | Resolution patterns and duration of retinal haemorrhages measured by two-dimensional retinal area pixel counts from sequential retinal imaging in childhood encephalopathies: a morphometric study |
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| المؤلفون: | Jones, Patricia A, Minns, Robert A, Tandon, Anamika, Fleck, Brian, Mulvihill, Alan |
| المساهمون: | Friends of the Sick Kids Foundation, Edinburgh, Scotland, Royal College of Surgeons Edinburgh, RS Macdonald Charitable Trust |
| المصدر: | BMJ Open Ophthalmology ; volume 4, issue 1, page e000275 ; ISSN 2397-3269 |
| بيانات النشر: | BMJ |
| سنة النشر: | 2019 |
| الوصف: | Objective To determine the time to resolution of different-layered retinal haemorrhages (RHs), and to describe the main patterns of their resolution in a group of children with encephalopathies. Methods and analysis From a prospective study of 114 children with traumatic and non-traumatic encephalopathies, 429 selected individual RHs (iRHs) from 18 children were serially imaged from admission using a RetCam. Photoshop and Scion Imaging software allowed calculation of RH area in pixels. Results Two patterns of the resolution were recognised on the basis of area measurements: a progressive decrease (pattern A, 60% of iRHs), and a form of asymmetrical decay in which iRHs first increased in size before then progressively decreasing (pattern B, 35% of iRHs). Within the pattern A group, the Kaplan-Meier median survival time (MST) (95% CI) was 10 (9.3 to 10.7) days for intra-RHs (IRHs) and 38 (10.8 to 65.2) days for pre-RHs (PRHs), log rank (Mantel-Cox) p=0.001. The mean percentage reduction in area per day was 12.5% for all iRHs, 14.5% for IRHs and 6.3% for PRHs. Conclusion Serial area measurements of iRHs revealed that 35% haemorrhages became temporarily larger before decreasing to resolution. Serially imaged selected RHs showed a longer MST for PRHs than for IRHs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/bmjophth-2019-000275 |
| الاتاحة: | http://dx.doi.org/10.1136/bmjophth-2019-000275 https://syndication.highwire.org/content/doi/10.1136/bmjophth-2019-000275 |
| رقم الانضمام: | edsbas.97FA4734 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjophth-2019-000275 |
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