Academic Journal
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals
| العنوان: | Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals |
|---|---|
| المؤلفون: | Murugadoss, Sivakumar, Vinković Vrček, Ivana, Schaffert, Alexandra, Paparella, Martin, Pem, Barbara, Sosnowska, Anita, Stępnik, Maciej, Martens, Marvin, Willighagen, Egon, L, Puzyn, Tomasz, Cimpan, Roxana, Lemaire, Frauke, Mertens, Birgit, Dusinska, Maria, Fessard, Valérie, Hoet, Peter, H. |
| المساهمون: | Department of Public Health and Primary Care, Catholic University of Leuven = Katholieke Universiteit Leuven (KU Leuven), Sciensano Bruxelles, Pasteur Network (Réseau International des Instituts Pasteur), Institute for Medical Research and Occupational Health, Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Rudjer Boskovic Institute Zagreb, QSAR lab, Maastricht University Maastricht, Department of Bioinformatics, Maastricht University Medical Center (BiGCaT), Faculty of Chemistry Univ Gdańsk, University of Gdańsk (UG), University of Bergen (UiB), Norwegian Institute for Air Research (NILU), Laboratoire de Fougères - ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), This work was funded by EUH2020 project (H2020-NMBP-13-2018 RIA): RiskGONE (Science-based Risk Governance of Nan-oTechnology) under grant agreement nº 814425. The work of Sivakumar Murugadoss and Alexandra Schaffert was funded by the European Union’s Horizon 2020 research and innovation program under grant agreement No. 101037090 (projectALTERNATIVE).The work of Ivana Vinković Vrček and Barbara Pem was additionally supported bythe “Research Cooperability” Program of the Croatian Science Foundation funded by the European Union from the European Social Fund under the Operational Programme Efficient Human Resources 2014–2020 (grant HRZZ-PZS-2019-02-4323). The work of Anita Sosnowska, Maciej Stępnik, Marvin Martens, Egon Willighagen, Tomasz Puzyn and Maria Dusinska has been also supported by EUH2020project(H2020-NMBP-14-2018 RIA): NanoSolveIT (Innovative Nanoinformatics models and tools: towards a Solid, verified and Integrated Approach to Predictive (eco)Toxicology) under grant agreement nº 814572. Mihaela Roxana Cimpan and Maria Dusinska have also been supported by the Research Council of Norway project NanoBioReal (Towards a reliable assessment of nanomaterial health effects using advanced biological models and assays) under the grant agreement nº 288768., European Project: 814425,H2020,RiskGONE(2019), European Project: 814572,NanoSolveIT |
| المصدر: | ISSN: 1868-596X. |
| بيانات النشر: | CCSD Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | Anses: HAL (Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail) |
| مصطلحات موضوعية: | Adverse Outcome Pathway, AOP, toxicology, toxicity, test, Chemical agents, nanomaterial, mitochondrion, toxicological test, safety, risk assessment, toxicologie, toxicité, agents chimiques, nanomatériau, mitochondrie, test toxicologique, sécurité, évaluation des risques, [SDV.TOX]Life Sciences [q-bio]/Toxicology |
| الوصف: | International audience ; The Adverse Outcome Pathway (AOP) framework plays a crucial role in the paradigm shift of toxicity testing towards the development and use of new approach methodologies. AOPs developed for chemicals are in theory applicable to nanomaterials (NMs). However, only subtle efforts have been made to integrate information on NM-induced toxicity into existing AOPs. In a previous study, we identified AOPs in the AOP-Wiki associated with the molecular initiating events (MIEs) and key events (KEs) reported for NMs in scientific literature. In a next step, we analyzed these AOPs and found that mitochondrial toxicity plays a significant role in several of them at the molecular and cellular levels. In this study, we aimed to generate hypothesis-based AOPs related to NM-induced mitochondrial toxicity. This was achieved by integrating science-based information collected on NM-induced mitochondrial toxicity into all existing AOPs in the AOP-Wiki, which already includes mitochondrial toxicity as a MIE/KE. The results showed that several AOPs in the AOP-Wiki related to the lung, liver, cardiovascular and nervous system, with extensively defined KEs and key event relationships (KERs), could be utilized to develop AOPs that are relevant for NMs. Our results also indicate that the majority of the studies included in our literature review were of poor quality, particularly in reporting NM physico-chemical characteristics, and NM-relevant mitochondrial MIEs were scarcely reported. This study highlights the potential role of NM-induced mitochondrial toxicity in human-relevant adverse outcomes and identifies useful AOPs in the AOP-Wiki for the development AOPs that are relevant for NMs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37606097; info:eu-repo/grantAgreement//814425/EU/Risk Governance of Nanotechnology/RiskGONE; info:eu-repo/grantAgreement//814572/EU/NanoSolveIT/NanoSolveIT; PUBMED: 37606097 |
| DOI: | 10.14573/altex.2305011 |
| الاتاحة: | https://anses.hal.science/anses-04199363 https://anses.hal.science/anses-04199363v1/document https://anses.hal.science/anses-04199363v1/file/Sivakumar14.pdf https://doi.org/10.14573/altex.2305011 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.97901438 |
| قاعدة البيانات: | BASE |
| DOI: | 10.14573/altex.2305011 |
|---|