Academic Journal
The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study.
| العنوان: | The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study. |
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| المؤلفون: | Stewardson, A.J., Allignol, Arthur, Beyersmann, Jan, Graves, Nicholas, Schumacher, Martin, Meyer, Rodolphe, Tacconelli, Evelina, de Angelis, Giulia, Farina, Claudio, Pezzoli, Fabio, Bertrand, Xavier, Gbaguidi-Haore, Houssein, Edgeworth, Jonathan, Tosas, Olga, Martinez, Jose A, Ayala-Blanco, M Pilar, Pan, Angelo, Zoncada, Alessia, Marwick, Charis A, Nathwani, Dilip, Seifert, Harald, Hos, Nina, Hagel, Stefan, Pletz, Mathias, Harbarth, Stephan |
| المساهمون: | Infection Control Programme, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland, Freiburg Center for Data Analysis and Modeling (FDM), Albert-Ludwigs-Universität Freiburg = University of Freiburg, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology Brisbane (QUT), Laboratoire de Biologie Moléculaire et Cellulaire du Cancer Luxembourg (LBMCC), Hôpital Kirchberg Luxembourg, Geneva University Hospital (HUG), Department of Infectious Diseases, Università cattolica del Sacro Cuore Milano (Unicatt), INFN Laboratori Nazionali di Legnaro, Unità di Microbiologia, AO "Ospedale San Carlo Borromeo", Hospital Papa Giovanni XXIII (Hosp P Giovanni XXIII), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Department of Infectious Diseases London, UK (School of Immunology and Microbial Sciences), King‘s College London, Universitätsklinikum Köln (Uniklinik Köln), Études sur les Sciences et les Techniques (EST), Université Paris-Sud - Paris 11 (UP11), Groupe d'histoire et diffusion des sciences d'Orsay (GHDSO), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Sud - Paris 11 (UP11), Hospital Clínic de Barcelona Catalonia, Spain, Divisione di Malattie Infettive, Istituti Ospitalieri di Cremona, Ninewells Hospital and Medical School Dundee, Feinberg School of Medicine, Northwestern University Evanston, Jena University Hospital Jena |
| المصدر: | ISSN: 1560-7917. |
| بيانات النشر: | HAL CCSD European Centre for Disease Prevention and Control |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Antimicrobial resistance, Escherichia coli, Meticillin-resistant Staphylococcus aureus (MRSA) in humans, Staphylococcus aureus, bacterial infections, bloodstream infection, multidrug resistance, MESH: Aged, MESH: Anti-Bacterial Agents, MESH: Cephalosporin Resistance, MESH: Enterobacteriaceae, MESH: Enterobacteriaceae Infections, MESH: Europe, MESH: Female, MESH: Health Care Costs, MESH: Hospital Mortality, MESH: Hospitals, MESH: Humans, MESH: Length of Stay, MESH: Male, MESH: Methicillin-Resistant Staphylococcus aureus, MESH: Middle Aged, MESH: Proportional Hazards Models, MESH: Retrospective Studies, MESH: Staphylococcal Infections, MESH: Staphylococcus aureus, MESH: Treatment Outcome, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology |
| الوصف: | International audience ; We performed a multicentre retrospective cohort study including 606,649 acute inpatient episodes at 10 European hospitals in 2010 and 2011 to estimate the impact of antimicrobial resistance on hospital mortality, excess length of stay (LOS) and cost. Bloodstream infections (BSI) caused by third-generation cephalosporin-resistant Enterobacteriaceae (3GCRE), meticillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA) increased the daily risk of hospital death (adjusted hazard ratio (HR) = 1.80; 95% confidence interval (CI): 1.34-2.42, HR = 1.81; 95% CI: 1.49-2.20 and HR = 2.42; 95% CI: 1.66-3.51, respectively) and prolonged LOS (9.3 days; 95% CI: 9.2-9.4, 11.5 days; 95% CI: 11.5-11.6 and 13.3 days; 95% CI: 13.2-13.4, respectively). BSI with third-generation cephalosporin-susceptible Enterobacteriaceae (3GCSE) significantly increased LOS (5.9 days; 95% CI: 5.8-5.9) but not hazard of death (1.16; 95% CI: 0.98-1.36). 3GCRE significantly increased the hazard of death (1.63; 95% CI: 1.13-2.35), excess LOS (4.9 days; 95% CI: 1.1-8.7) and cost compared with susceptible strains, whereas meticillin resistance did not. The annual cost of 3GCRE BSI was higher than of MRSA BSI. While BSI with S. aureus had greater impact on mortality, excess LOS and cost than Enterobacteriaceae per infection, the impact of antimicrobial resistance was greater for Enterobacteriaceae. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/27562950; PUBMED: 27562950; PUBMEDCENTRAL: PMC4998424 |
| DOI: | 10.2807/1560-7917.ES.2016.21.33.30319 |
| الاتاحة: | https://hal.science/hal-01506821 https://hal.science/hal-01506821v1/document https://hal.science/hal-01506821v1/file/eurosurv-21-30319.pdf https://doi.org/10.2807/1560-7917.ES.2016.21.33.30319 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.978C0A08 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2807/1560-7917.ES.2016.21.33.30319 |
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