التفاصيل البيبلوغرافية
| العنوان: |
Presentation_1_GABAB Receptor-Mediated Regulation of Dendro-Somatic Synergy in Layer 5 Pyramidal Neurons.pdf |
| المؤلفون: |
Jan M. Schulz (11330949), Jim W. Kay (11330952), Josef Bischofberger (304102), Matthew E. Larkum (6731522) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Cell Biology, Neuroscience, Cellular Nervous System, Central Nervous System, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), Protein Trafficking, neocortex, dendrite, interneuron, neurogliaform cells, GIRK channels, interhemispheric inhibition, L-type calcium channels, HCN channels – h current |
| الوصف: |
Synergistic interactions between independent synaptic input streams may fundamentally change the action potential (AP) output. Using partial information decomposition, we demonstrate here a substantial contribution of synergy between somatic and apical dendritic inputs to the information in the AP output of L5b pyramidal neurons. Activation of dendritic GABA B receptors (GABA B Rs), known to decrease APs in vivo, potently decreased synergy and increased somatic control of AP output. Synergy was the result of the voltage-dependence of the transfer resistance between dendrite and soma, which showed a two-fold increase per 28.7 mV dendritic depolarization. GIRK channels activated by dendritic GABA B Rs decreased voltage-dependent transfer resistances and AP output. In contrast, inhibition of dendritic L-type Ca 2+ channels prevented high-frequency bursts of APs, but did not affect dendro-somatic synergy. Finally, we show that NDNF-positive neurogliaform cells effectively control somatic AP via synaptic activation of dendritic GIRK channels. These results uncover a novel inhibitory mechanism that powerfully gates cellular information flow in the cortex. |
| نوع الوثيقة: |
conference object |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/presentation/Presentation_1_GABAB_Receptor-Mediated_Regulation_of_Dendro-Somatic_Synergy_in_Layer_5_Pyramidal_Neurons_pdf/16439247 |
| DOI: |
10.3389/fncel.2021.718413.s001 |
| الاتاحة: |
https://doi.org/10.3389/fncel.2021.718413.s001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.977544F9 |
| قاعدة البيانات: |
BASE |