Academic Journal
The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes
| العنوان: | The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes |
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| المؤلفون: | Fourlanos, S, Varney, MD, Tait, BD, Morahan, G, Honeyman, MC, Colman, PG, Harrison, LC |
| بيانات النشر: | AMER DIABETES ASSOC |
| سنة النشر: | 2008 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | OBJECTIVE: The rising incidence of type 1 diabetes has been attributed to environment, implying a lesser role for genetic susceptibility. However, the rise could be accounted for by either more cases with classic high-risk genes or by cases with other risk genes. Separately, for any degree of genetic susceptibility, age at presentation may decrease in a permissive environment. To examine these possibilities, human leukocyte antigen (HLA) class II DRB1 genes known to confer risk for type 1 diabetes were analyzed in relation to year of birth and age at diagnosis over the last five decades. RESEARCH DESIGN AND METHODS: Caucasoid subjects (n = 462) diagnosed with type 1 diabetes before age 18 between 1950 and 2005 were DRB1 genotyped. RESULTS: Mean +/- SD age at diagnosis, 8.5 +/- 4.5 years, did not differ across decades. Recent diagnosis was associated with a lower proportion but unchanged incidence of the highest-risk DRB1 genotype DR3,4 (2000-2005, 28% vs. 1950-1969, 79%; P < 0.0001) and a higher proportion of lower-risk genotypes DR4,X and DR3,X (2000-2005, 48% vs. 1950-1969, 20%; P = 0.0002). The frequency of the DRX,X genotype was low ( |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0149-5992 1935-5548 |
| Relation: | pii: dc08-0239; Fourlanos, S., Varney, M. D., Tait, B. D., Morahan, G., Honeyman, M. C., Colman, P. G. & Harrison, L. C. (2008). The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. DIABETES CARE, 31 (8), pp.1546-1549. https://doi.org/10.2337/dc08-0239.; http://hdl.handle.net/11343/265325 |
| الاتاحة: | http://hdl.handle.net/11343/265325 |
| Rights: | CC BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0 |
| رقم الانضمام: | edsbas.96E42A8F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 01495992 19355548 |
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