Academic Journal
Retinotopic cortical mapping in objective functional monitoring of macular therapy
| العنوان: | Retinotopic cortical mapping in objective functional monitoring of macular therapy |
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| المؤلفون: | Ritter, Markus, Hummer, Allan, Pawloff, Maximilian, Ledolter, Anna A, Linhardt, David, Woletz, Michael, Deak, Gabor Gyoergy, Sacu, Stefan, Ristl, Robin, Ramazanova, Dariga, Holder, Graham E, Windischberger, Christian, Schmidt-Erfurth, Ursula Margarethe |
| المساهمون: | Novartis |
| المصدر: | British Journal of Ophthalmology ; volume 109, issue 1, page 98-106 ; ISSN 0007-1161 1468-2079 |
| بيانات النشر: | BMJ |
| سنة النشر: | 2024 |
| الوصف: | Background/Aims To determine the suitability of functional MRI (fMRI) as an objective measure of macular function following therapeutic intervention; conventional psychophysical measures rely heavily on patient compliance. Methods Twenty patients with neovascular age-related macular degeneration (nAMD) were studied with high-resolution fMRI, visual acuity, reading accuracy and speed, contrast sensitivity (CS) and microperimetry (MP) before and after 3 monthly intravitreal injections of ranibizumab. Population-receptive field retinotopic maps calculated from fMRI data were compared with psychophysical measures and optical coherence tomography. Results Best-corrected visual acuity (BCVA) responders (≥5 letters) showed an increase of 29.5% in activated brain area, while non-responders showed a decrease of 0.8%. Radial histograms over eccentricity allowed quantification of the absolute number of significant voxels and thus differences before and after treatment. Responders showed increases in foveal (α<0.5°) activation, while non-responders did not. Absence of intraretinal fluid and preservation of outer retinal layers was associated with higher numbers of active V1 voxels and better BCVA. Higher voxel numbers were associated with improved reading performance and, less marked, with BCVA, CS and MP. Conclusion The data show that retinotopic mapping using fMRI can successfully be applied objectively to evaluate the therapeutic response in nAMD patients treated with anti-vascular endothelial growth factor therapy. This demonstrates the ability of retinotopic mapping to provide an objective assessment of functional recovery at a cortical level; the technique can therefore be applied, in other degenerative macular diseases, to the assessment of potential therapeutic interventions such as gene therapy or cell replacement therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/bjo-2021-320723 |
| الاتاحة: | https://doi.org/10.1136/bjo-2021-320723 https://syndication.highwire.org/content/doi/10.1136/bjo-2021-320723 |
| رقم الانضمام: | edsbas.96AE6173 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bjo-2021-320723 |
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