Academic Journal
Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety
| العنوان: | Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety |
|---|---|
| المؤلفون: | AMR, Abdel-Galil El-Sayed, ABDEL-HAFEZ, Naglaa Abdel-Samei, MOHAMED, Salwa Fahem, ABDALLA, Mohamed Mostafa |
| المصدر: | Volume: 33, Issue: 3 421-432 ; 1300-0527 ; 1303-6130 ; Turkish Journal of Chemistry |
| بيانات النشر: | TÜBİTAK TUBITAK |
| سنة النشر: | 2009 |
| المجموعة: | DergiPark Akademik (E-Journals) |
| مصطلحات موضوعية: | Pyrimidine,pyrimidinethione,thiazolopyrimidine,antiarrhythmic activity. |
| الوصف: | We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide\textregistered and Lidocaine\textregistered as positive antiarrhythmic controls. ; We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide\textregistered and Lidocaine\textregistered as positive antiarrhythmic controls. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Turkish |
| Relation: | https://dergipark.org.tr/tr/download/article-file/123744; https://dergipark.org.tr/tr/pub/tbtkchem/issue/11904/142321 |
| الاتاحة: | https://dergipark.org.tr/tr/pub/tbtkchem/issue/11904/142321 |
| رقم الانضمام: | edsbas.96ABFDDF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |