Academic Journal
Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
| العنوان: | Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk |
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| المؤلفون: | Valassi, Elena, Manichanh, Chaysavanh, Amodru, Vincent, Fernández, Pedro González, Gaztambide, Sonia, Yañez, Francisca, Martel-Duguech, Luciana, Puig-Domingo, Manel, Webb, Susan M. |
| المساهمون: | Fundació d'Investigació Sant Pau |
| المصدر: | Frontiers in Endocrinology ; volume 14 ; ISSN 1664-2392 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2023 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Background Patients with Cushing’s disease (CD) in remission maintain an increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis) have been associated with several cardiometabolic risk factors. Methods Twenty-eight female non-diabetic patients with CD in remission with a mean ± SD) age of 51 ± 9 years, mean ( ± SD) BMI, 26 ± 4, median (IQR) duration of remission, 11(4) years and 24 gender-, age, BMI–matched controls were included. The V4 region of the bacterial 16S rDNA was PCR amplified and sequenced to analyse microbial alpha diversity (Chao 1 index, observed number of species, Shannon index) and beta diversity analysis through the Principal Coordinates Analysis (PCoA) of weighted and unweighted UniFrac distances. Inter-group difference in microbiome composition was analysed using MaAsLin2. Results The Chao 1 index was lower in CD as compared with controls (Kruskal-Wallis test, q = 0.002), indicating lower microbial richness in the former. Beta diversity analysis showed that faecal samples from CS patients clustered together and separated from the controls (Adonis test, p<0.05). Collinsella , a genus form of the Actinobacteria phylum was present in CD patients only, whereas Sutterella , a genus from Proteobacteria phylum , was scarcely detectable/undetectable in CD patients as well as Lachnospira , a genus of the Lachnospiraceae family of the Firmicutes phylum. In CS, the Chao 1 index was associated with fibrinogen levels and inversely correlated with both triglyceride concentrations and the HOMA-IR index (p<0.05). Conclusions Patients with CS in remission have gut microbial dysbiosis which may be one of the mechanisms whereby cardiometabolic dysfunctions persist after “cure”. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fendo.2023.1074757 |
| DOI: | 10.3389/fendo.2023.1074757/full |
| الاتاحة: | http://dx.doi.org/10.3389/fendo.2023.1074757 https://www.frontiersin.org/articles/10.3389/fendo.2023.1074757/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.96A6D89B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fendo.2023.1074757 |
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