Academic Journal
Metabolomic profiling in LRRK2-related Parkinson's disease.
| العنوان: | Metabolomic profiling in LRRK2-related Parkinson's disease. |
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| المؤلفون: | Krisztina K Johansen, Lei Wang, Jan O Aasly, Linda R White, Wayne R Matson, Claire Henchcliffe, M Flint Beal, Mikhail Bogdanov |
| المصدر: | PLoS ONE, Vol 4, Iss 10, p e7551 (2009) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2009 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Mutations in LRRK2 gene represent the most common known genetic cause of Parkinson's disease (PD).We used metabolomic profiling to identify biomarkers that are associated with idiopathic and LRRK2 PD. We compared plasma metabolomic profiles of patients with PD due to the G2019S LRRK2 mutation, to asymptomatic family members of these patients either with or without G2019S LRRK2 mutations, and to patients with idiopathic PD, as well as non-related control subjects. We found that metabolomic profiles of both idiopathic PD and LRRK2 PD subjects were clearly separated from controls. LRRK2 PD patients had metabolomic profiles distinguishable from those with idiopathic PD, and the profiles could predict whether the PD was secondary to LRRK2 mutations or idiopathic. Metabolomic profiles of LRRK2 PD patients were well separated from their family members, but there was a slight overlap between family members with and without LRRK2 mutations. Both LRRK2 and idiopathic PD patients showed significantly reduced uric acid levels. We also found a significant decrease in levels of hypoxanthine and in the ratios of major metabolites of the purine pathway in plasma of PD patients.These findings show that LRRK2 patients with the G2019S mutation have unique metabolomic profiles that distinguish them from patients with idiopathic PD. Furthermore, asymptomatic LRRK2 carriers can be separated from gene negative family members, which raises the possibility that metabolomic profiles could be useful in predicting which LRRK2 carriers will eventually develop PD. The results also suggest that there are aberrations in the purine pathway in PD which may occur upstream from uric acid. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC2761616?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/4307730a405e40edaf52680855cfdb51 |
| DOI: | 10.1371/journal.pone.0007551 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0007551 https://doaj.org/article/4307730a405e40edaf52680855cfdb51 |
| رقم الانضمام: | edsbas.966B3513 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0007551 |