Academic Journal
Diarrhea Associated with Lopinavir/Ritonavir-Based Therapy ; Results of a Meta-Analysis of 1469 HIV-1-Infected Participants
| العنوان: | Diarrhea Associated with Lopinavir/Ritonavir-Based Therapy ; Results of a Meta-Analysis of 1469 HIV-1-Infected Participants |
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| المؤلفون: | Wegzyn, Colleen M., Fredrick, Linda M., Stubbs, Roxann O., Woodward, William C., Norton, Michael |
| المصدر: | Journal of the International Association of Physicians in AIDS Care ; volume 11, issue 4, page 252-259 ; ISSN 1545-1097 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2012 |
| الوصف: | Background Antiretroviral therapy is associated with adverse events (AEs). The most frequently reported AE associated with lopinavir/ritonavir (LPV/r) containing regimens is diarrhea. The objective of this meta-analysis is to describe the incidence, prevalence, and duration of diarrhea in individuals taking LPV/r. Methods This is a meta-analysis of Abbott-conducted clinical trials. Inclusion criteria included prospective randomized clinical trials with the LPV/r tablet formulation and had AE data (moderate/severe diarrhea) available through 48 weeks of treatment. Results Three trials (total 1469 participants) met the inclusion criteria. In all, 11.2% of participants reported moderate/severe diarrhea by week 8, with median time to resolution of 7.4 weeks. The overall 48-week incidence of moderate/severe diarrhea was 15.5%. The discontinuation rate due to moderate/severe diarrhea was 1.3%. Conclusions Moderate/severe diarrhea occurred in less than 1 in 6 participants taking LPV/r, typically started in the first 8 weeks of treatment and infrequently resulted in premature discontinuation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1545109712442984 |
| الاتاحة: | http://dx.doi.org/10.1177/1545109712442984 http://journals.sagepub.com/doi/pdf/10.1177/1545109712442984 http://journals.sagepub.com/doi/full-xml/10.1177/1545109712442984 |
| Rights: | http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.965D158 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1545109712442984 |
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