Academic Journal
Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure
| العنوان: | Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure |
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| المؤلفون: | Danielsen, Pernille Høgh, Poulsen, Sarah Søs, Knudsen, Kristina Bram, Clausen, Per Axel, Jensen, Keld Alstrup, Wallin, Håkan, Vogel, Ulla |
| المصدر: | Danielsen , P H , Poulsen , S S , Knudsen , K B , Clausen , P A , Jensen , K A , Wallin , H & Vogel , U 2024 , ' Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure ' , Environmental Toxicology and Pharmacology , vol. 107 , 104413 . https://doi.org/10.1016/j.etap.2024.104413 |
| سنة النشر: | 2024 |
| المجموعة: | Technical University of Denmark: DTU Orbit / Danmarks Tekniske Universitet |
| مصطلحات موضوعية: | Carbon nanotubes, Inflammation, Acute phase response, Nanomaterial, Metals, Toxicity |
| الوصف: | Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 days or 3 months. This resulted in a unique dataset, which was used to identify physicochemical predictors of pulmonary inflammation and systemic acute phase response. MWCNT diameter and SWCNT specific surface area were predictive of lower and higher neutrophil influx, respectively. Manganese and iron were shown to be predictive of higher neutrophil influx at day 1 post-exposure, whereas nickel content interestingly was predictive of lower neutrophil influx at all three time points and of lowered acute phase response at day 1 and 3 months post-exposure. It was not possible to separate effects of properties such as specific surface area and length in the multiple regression analyses due to co-variation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://orbit.dtu.dk/en/publications/c6cef14d-22c7-4655-b42a-868efae2085f |
| DOI: | 10.1016/j.etap.2024.104413 |
| الاتاحة: | https://orbit.dtu.dk/en/publications/c6cef14d-22c7-4655-b42a-868efae2085f https://doi.org/10.1016/j.etap.2024.104413 https://backend.orbit.dtu.dk/ws/files/356729700/1-s2.0-S138266892400053X-main_1_.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.963C55 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.etap.2024.104413 |
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