Academic Journal
Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination
| العنوان: | Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination |
|---|---|
| المؤلفون: | Sokal, Aurélien, Bastard, Paul, Chappert, Pascal, Barba-Spaeth, Giovanna, Fourati, Slim, Vanderberghe, Alexis, Lagouge-Roussey, Pauline, Meyts, Isabelle, Gervais, Adrian, Bouvier-Alias, Magali, Azzaoui, Imane, Fernández, Ignacio, de la Selle, Andréa, Zhang, Qian, Bizien, Lucy, Pellier, Isabelle, Linglart, Agnès, Rothenbuhler, Anya, Marcoux, Estelle, Anxionnat, Raphael, Cheikh, Nathalie, Léger, Juliane, Amador-Borrero, Blanca, Fouyssac, Fanny, Menut, Vanessa, Goffard, Jean-Christophe, Storey, Caroline, Demily, Caroline, Mallebranche, Coralie, Troya, Jesus, Pujol, Aurora, Zins, Marie, Tiberghien, Pierre, Gray, Paul, Mcnaughton, Peter, Sullivan, Anna, Peake, Jane, Levy, Romain, Languille, Laetitia, Rodiguez-Gallego, Carlos, Boisson, Bertrand, Gallien, Sébastien, Neven, Bénédicte, Michel, Marc, Godeau, Bertrand, Abel, Laurent, Rey, Felix, Weill, Jean-Claude, Reynaud, Claude-Agnès, Tangye, Stuart, Casanova, Jean-Laurent, Mahévas, Matthieu |
| المساهمون: | Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Rockefeller University New York, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Virologie Structurale - Structural Virology, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), CHU Henri Mondor Créteil, Catholic University of Leuven = Katholieke Universiteit Leuven (KU Leuven), INSERM U955, team 2. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France. Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université d'Angers (UA), Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Saclay, Hôpital Nord Franche-Comté Hôpital de Trévenans (HNFC), Service de pédiatrie CHRU Besançon, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), GHU AP-HP Nord - Université Paris Cité, Hôpital Lariboisière-Fernand-Widal APHP, Centre Hospitalier Universitaire de Nancy (CHU Nancy), Hôpital Mère-Enfant Hôpital Hôtel Dieu, Nantes, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Université libre de Bruxelles (ULB), Hôpital Robert Debré, Centre Hospitalier le Vinatier Bron, Hospital Universitario Infanta Leonor Madrid, Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute (IDIBELL), Université Paris Cité (UPCité), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Etablissement Français du Sang La Plaine Saint-Denis (EFS), Sydney Children's hospital, University of New South Wales Sydney (UNSW), Children’s Health Queensland Brisbane (CHQ), Hôpital Necker - Enfants Malades AP-HP, Universidad Fernando Pessoa Canarias Las Palmas de Gran Canaria, Spain, Garvan Institute of medical research, Howard Hughes Medical Institute New York (HHMI), Howard Hughes Medical Institute (HHMI)-New York University School of Medicine, NYU System (NYU)-NYU System (NYU)-Rockefeller University New York -Columbia University Irving Medical Center (CUIMC), Funder(s): Agence Nationale de la Recherche Award Id(s): ANR-21-RHUS-0008, ANR-10-IAHU-01, ANR-10-LABX-62-IBEID , ANR-20-CE93-003Funder(s): Fondation pour la Recherche MédicaleAward Id(s): MEMO-COV-2-FRMFunder(s): Institut PasteurFunder(s): Agence Nationale de Recherches sur le Sida et les Hépatites ViralesFunder(s): Howard Hughes Medical InstituteFunder(s): Rockefeller UniversityFunder(s): St. Giles FoundationFunder(s): National Institutes of Health Award Id(s): R01AI088364, R01AI163029, UL1TR001866Funder(s): National Center for Advancing Translational SciencesFunder(s): Fisher Center for Alzheimer’s Research FoundationFunder(s): Meyer FoundationFunder(s): JPB FoundationFunder(s): French Foundation for Medical Research Award Id(s): EQU201903007798, EA20170638020Funder(s): European Union’s Horizon 2020 Award Id(s): 824110Funder(s): Square FoundationFunder(s): Fondation du SouffleFunder(s): French Ministry of Higher Education, Research, and Innovation Award Id(s): MESRI-COVID-19Funder(s): Institut National de la Santé et de la Recherche MédicaleFunder(s): Fondation Bettencourt SchuellerFunder(s): CSL BehringFunder(s): KU Leuven Award Id(s): C16/18/007Funder(s): http://dx.doi.org/10.13039/501100003130 Award Id(s): G0C8517N, G0B5120N, G0E8420NFunder(s): Jeffrey Modell FoundationFunder(s): National Health and Medical Research Council Award Id(s): 1176665Funder(s): Allergy and Immunology Foundation of AustraliaFunder(s): John Brown Cook FoundationFunder(s): Fondation Princesse GraceFunder(s): Comité ad-hoc de pilotage national des essais thérapeutiques et autres recherchesFunder(s): Assistance Publique—Hôpitaux de Paris Award Id(s): MEMO-COV-2Funder(s): Société Nationale de Médecine InterneFunder(s): ANRS Nord-Sud Award Id(s): ANRS-COV05Funder(s): ANR-RHU Award Id(s): ANR-21-RHUS-08 (COVIFERON)Funder(s): HORIZON-HLTH-2021-DISEASE-04 Award Id(s): 01057100Funder(s): Grandir - Fonds de solidarité pour l’enfanceFunder(s): SCOR Corporate Foundation for ScienceFunder(s): REACTing-INSERMFunder(s): University of Paris CitéFunder(s): Imagine InstituteFunder(s): VIB GC PIDFunder(s): European Research Council Award Id(s): ERC-StG MORE2ADA2, ANR-21-RHUS-0008,COVIFERON,Covid-19 and interferons: from discovery to therapy(2021), ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-20-CE93-0003,GENVIR,Analyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévères(2020), European Project: 824110,H2020-INFRAIA-2018-1,EASI-Genomics(2019), European Project: 948959,ERC-2020-STG,MORE2ADA2(2021) |
| المصدر: | ISSN: 0022-1007. |
| بيانات النشر: | HAL CCSD Rockefeller University Press |
| سنة النشر: | 2023 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology |
| الوصف: | International audience ; Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)–specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36342455; info:eu-repo/grantAgreement//824110/EU/European Advanced infraStructure for Innovative Genomics/EASI-Genomics; info:eu-repo/grantAgreement//948959/EU/Multi-omics research applied to Human ADA2 deficiency and beyond/MORE2ADA2; pasteur-03847416; https://pasteur.hal.science/pasteur-03847416; https://pasteur.hal.science/pasteur-03847416/document; https://pasteur.hal.science/pasteur-03847416/file/jem_20220258.pdf; PUBMED: 36342455 |
| DOI: | 10.1084/jem.20220258 |
| الاتاحة: | https://pasteur.hal.science/pasteur-03847416 https://pasteur.hal.science/pasteur-03847416/document https://pasteur.hal.science/pasteur-03847416/file/jem_20220258.pdf https://doi.org/10.1084/jem.20220258 |
| Rights: | http://creativecommons.org/licenses/by-nc-sa/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.96299331 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20220258 |
|---|