التفاصيل البيبلوغرافية
| العنوان: |
DataSheet_2_Mechanism and Molecular Network of RBM8A-Mediated Regulation of Oxaliplatin Resistance in Hepatocellular Carcinoma.zip |
| المؤلفون: |
Rong Liang (587636), Jinyan Zhang (759953), Zhihui Liu (95891), Ziyu Liu (2566468), Qian Li (114642), Xiaoling Luo (2553286), Yongqiang Li (420174), Jiazhou Ye (5712152), Yan Lin (285018) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, RNA-binding motif protein 8A, hepatocellular carcinoma, oxaliplatin, drug resistance, histone deacetylase 9, molecular network |
| الوصف: |
RNA-binding motif protein 8A (RBM8A) is abnormally overexpressed in hepatocellular carcinoma (HCC) and involved in the epithelial-mesenchymal transition (EMT). The EMT plays an important role in the development of drug resistance, suggesting that RBM8A may be involved in the regulation of oxaliplatin (OXA) resistance in HCC. Here we examined the potential involvement of RBM8A and its downstream pathways in OXA resistance using in vitro and in vivo models. RBM8A overexpression induced the EMT in OXA-resistant HCC cells, altering cell proliferation, apoptosis, migration, and invasion. Moreover, whole-genome microarrays combined with bioinformatics analysis revealed that RBM8A has a wide range of transcriptional regulatory capabilities in OXA-resistant HCC, including the ability to regulate several important tumor-related signaling pathways. In particular, histone deacetylase 9 (HDAC9) emerged as an important mediator of RBM8A activity related to OXA resistance. These data suggest that RBM8A and its related regulatory pathways represent potential markers of OXA resistance and therapeutic targets in HCC. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/DataSheet_2_Mechanism_and_Molecular_Network_of_RBM8A-Mediated_Regulation_of_Oxaliplatin_Resistance_in_Hepatocellular_Carcinoma_zip/13624838 |
| DOI: |
10.3389/fonc.2020.585452.s002 |
| الاتاحة: |
https://doi.org/10.3389/fonc.2020.585452.s002 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.95E635B8 |
| قاعدة البيانات: |
BASE |