Academic Journal
Effects of iron on extracellular and intracellular growth of penicillium marneffei
| العنوان: | Effects of iron on extracellular and intracellular growth of penicillium marneffei |
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| المؤلفون: | D. Taramelli, S. Brambilla, G. Sala, A. Bruccoleri, C. Tognazioli, L. Riviera Uzielli, J. R. Boelaert |
| المساهمون: | D. Taramelli, S. Brambilla, G. Sala, A. Bruccoleri, C. Tognazioli, L. Riviera Uzielli, J.R. Boelaert |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2000 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | animal, deferoxamine, human, interferon-gamma, iron, iron overload, lipopolysaccharide, mice, nitric oxide, penicillium, Settore MED/04 - Patologia Generale |
| الوصف: | Killing of intracellular Penicillium marneffei conidia is demonstrated in gamma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cells. Iron overload significantly reduces the antifungal activity of macrophages. Likewise, exogenous iron enhances and iron chelators inhibit the extracellular growth of P. marneffei. These results suggest that iron availability critically affects immunity to and the pathogenicity of P. marneffei. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/10678997; info:eu-repo/semantics/altIdentifier/wos/WOS:000085407400098; volume:68; issue:3; firstpage:1724; lastpage:1726; numberofpages:3; journal:INFECTION AND IMMUNITY; http://hdl.handle.net/2434/245052; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033970284 |
| DOI: | 10.1128/IAI.68.3.1724-1726.2000 |
| الاتاحة: | http://hdl.handle.net/2434/245052 https://doi.org/10.1128/IAI.68.3.1724-1726.2000 |
| رقم الانضمام: | edsbas.95DC7EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/IAI.68.3.1724-1726.2000 |
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