التفاصيل البيبلوغرافية
| العنوان: |
Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells |
| المؤلفون: |
Coffey, E T, Akerman, K E, Courtney, M J |
| المصدر: |
Coffey , E T , Akerman , K E & Courtney , M J 1997 , ' Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells ' , Neuroscience Letters , vol. 227 , no. 3 , pp. 177-80 . https://doi.org/10.1016/s0304-3940(97)00335-2 |
| سنة النشر: |
1997 |
| مصطلحات موضوعية: |
Animals, Antibodies, Monoclonal, Brain-Derived Neurotrophic Factor/pharmacology, Cerebellum/chemistry, Immunoblotting, Proto-Oncogene Proteins c-fos/chemistry, Rats, Receptor, Ciliary Neurotrophic Factor, Receptors, Nerve Growth Factor/analysis, Signal Transduction/physiology, Synaptophysin/analysis, tau Proteins/analysis, socio, stat |
| الوصف: |
We have examined the effects of neurotrophins brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) on the expression of the maturation-specific proteins synaptophysin and tau, and the growth-associated protein (GAP)-43 in cerebellar granule cells. We find that BDNF but not NGF rapidly (within 2 h) upregulates levels of synaptophysin, tau and c-Fos correlating with expression of the neurotrophin receptor TrkB. The rapid increase in synaptophysin is not preceded by c-Fos elevation suggesting a post-transcriptional mechanism may be involved. In contrast, no upregulation of GAP-43 levels are seen within this time period. Phorbol ester mimics the effects of BDNF, indicating that protein kinase C (PKC) is either a component of, or feeds into the signalling mechanism. We conclude that BDNF, characterized to be survival promoting early in differentiation of cerebellar granule cells, enhances maturation at a later stage. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
https://research.abo.fi/en/publications/c392f833-5fca-4f6b-8cd7-bade708cfbab |
| الاتاحة: |
https://research.abo.fi/en/publications/c392f833-5fca-4f6b-8cd7-bade708cfbab |
| Rights: |
undefined |
| رقم الانضمام: |
edsbas.95B00993 |
| قاعدة البيانات: |
BASE |