Conference
Correlation between polymorphisms at promoter region of the NOS3 gene and prostate cancer in Serbian population
| العنوان: | Correlation between polymorphisms at promoter region of the NOS3 gene and prostate cancer in Serbian population |
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| المؤلفون: | Brajušković, G., Branković, A., Savić Pavićević, D., Mirčetić, J., Cerović, S., Tomović, S., Vuković, I., Vukotić, V., Romac, S. |
| المصدر: | Virchows Archiv : European Journal of Pathology (abstracts) |
| بيانات النشر: | Helsinki . European Society of Pathology |
| سنة النشر: | 2011 |
| المجموعة: | Jakov - Repository of the University of Criminal Investigation and Police Studies, Belgrade / Repozitorijum Kriminalističko-policijskog univerziteta |
| مصطلحات موضوعية: | pathology |
| الوصف: | Objective: Prostate cancer (PC) is the most common malignant disease in men in the Western Hemisphere. The NOS3 has a role in vascular development, regulation of the vascular tone and tumor growth in PC. In previous studies, the -786 T > C polymorphism was found to be the most important promoter alteration of the NOS3 gene that may affect the PC progression. The purpose of this study was to evaluate 786 T > C, -764A > G, -714 G > T, -690 C > T and -649 G > A polymorphisms in the promoter region of NOS3 gene as genetic indicators of the relative risk of the PC occurrence in Serbian population. Method: In this study, we characterized these polymorphisms by PCR amplification, followed by capillary electrophoresis sequencing in the peripheral blood samples from 50 patients with PC, 50 benign hyperplasia patients and 50 individuals over 40 years of age who showed no clinical signs of any prostatic disease, that were used as controls. Results: Three of the analyzed polymorphisms (-764A > G, -714 G > T and -649 G > A) were not detected during this study. It is interesting to observe that when the -786 T > C polymorphism was present, -690 C > T polymorphism was also found. Conclusion: This study demonstrates no association between the -786 T > C polymorphism in the promoter of the NOS3 gene and the development of PC. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| تدمد: | 0945-6317 |
| Relation: | http://jakov.kpu.edu.rs/handle/123456789/1553; https://hdl.handle.net/21.15107/rcub_jakov_1553; 000293920500895 |
| الاتاحة: | http://jakov.kpu.edu.rs/handle/123456789/1553 https://hdl.handle.net/21.15107/rcub_jakov_1553 |
| Rights: | restrictedAccess ; https://creativecommons.org/licenses/by/4.0/ ; BY |
| رقم الانضمام: | edsbas.959BDD83 |
| قاعدة البيانات: | BASE |
| تدمد: | 09456317 |
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