Academic Journal
Fecal calprotectin: assessment of a rapid test
| العنوان: | Fecal calprotectin: assessment of a rapid test |
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| المؤلفون: | Vestergaard, T A, Nielsen, Søren Lyhne, Dahlerup, J F, Hornung, N |
| المصدر: | Vestergaard , T A , Nielsen , S L , Dahlerup , J F & Hornung , N 2008 , ' Fecal calprotectin: assessment of a rapid test ' , Scandinavian Journal of Clinical & Laboratory Investigation , vol. 68 , no. 4 , pp. 343-7 . https://doi.org/10.1080/00365510701576198 |
| سنة النشر: | 2008 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Confidence Intervals, Diagnostic Tests, Routine, Enzyme-Linked Immunosorbent Assay, Feces, Female, Humans, Leukocyte L1 Antigen Complex, Male, Predictive Value of Tests, Sensitivity and Specificity |
| الوصف: | Udgivelsesdato: 2008-null ; BACKGROUND: Calprotectin, a protein found mainly in neutrophil granulocytes, is used as an inflammatory marker, while the fecal concentration of the protein is used to detect gastrointestinal (GI) inflammation. MATERIAL AND METHODS: Fecal calprotectin in 100 stool samples was measured by the ELISA method and by a new rapid test. Eighty-two patients had fecal calprotectin measured for clinical reasons and delivered 95 stool samples. The rest were delivered by healthy volunteers. RESULTS: The association between the two tests was statistically significant (p<0.0001, chi(2) test). With calprotectin values <15 microg/g, the sensitivity and specificity of the new rapid test was 96 % (95 % confidence interval (CI), 87-100 %) and 70 % (CI, 55-83 %), respectively, with a negative predictive value of 94 % (CI, 81-99 %). With values >15 microg/g, the rapid test was less accurate, thus rendering results in this range difficult to interpret. CONCLUSIONS: The new rapid test is useful as a screening test for excluding GI inflammation when the cut-off of 15 microg/g is used. With fecal calprotectin concentrations >15 microg/g, the rapid test should be supplemented by quantitative measurement. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1080/00365510701576198 |
| الاتاحة: | https://pure.au.dk/portal/da/publications/fecal-calprotectin-assessment-of-a-rapid-test(ae54d6f0-041a-11de-a987-000ea68e967b).html https://doi.org/10.1080/00365510701576198 |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.959822A0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/00365510701576198 |
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