Academic Journal
Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR‐132/MeCP2 pathway
| العنوان: | Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR‐132/MeCP2 pathway |
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| المؤلفون: | Xie, Ao‐Ji, Hou, Tong‐Yao, Xiong, Wan, Huang, He‐Zhou, Zheng, Jie, Li, Ke, Man, Heng‐Ye, Hu, Ya‐Zhuo, Han, Zhi‐Tao, Zhang, Hong‐Hong, Wei, Na, Wang, Jian‐Zhi, Liu, Dan, Lu, Youming, Zhu, Ling‐Qiang |
| المساهمون: | National Natural Science Foundation of China |
| المصدر: | Aging Cell ; volume 18, issue 3 ; ISSN 1474-9718 1474-9726 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Tauopathies are a class of neurodegenerative diseases that are characterized by pathological aggregation of tau protein, which is accompanied by synaptic disorders. However, the role of tau in endocytosis, a fundamental process in synaptic transmission, remains elusive. Here, we report that forced expression of human tau (hTau) in mouse cortical neurons impairs endocytosis by decreasing the level of the GTPase dynamin 1 via disruption of the miR‐132‐MeCP2 pathway; this process can also be detected in the brains of Alzheimer's patients and hTau mice. Our results provide evidence for a novel role of tau in the regulation of presynaptic function. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/acel.12929 |
| الاتاحة: | http://dx.doi.org/10.1111/acel.12929 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Facel.12929 https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12929 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/acel.12929 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.9568A8D1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/acel.12929 |
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