Academic Journal
Action potential threshold variability for different electrostimulation models and its potential impact on occupational exposure limit values
| العنوان: | Action potential threshold variability for different electrostimulation models and its potential impact on occupational exposure limit values |
|---|---|
| المؤلفون: | Soyka, Florian, Tarnaud, Thomas, Altekoester, Carsten, Schoeters, Ruben, Plovie, Tom, Joseph, Wout, Tanghe, Emmeric |
| المصدر: | BIOELECTROMAGNETICS ; ISSN: 0197-8462 ; ISSN: 1521-186X |
| سنة النشر: | 2025 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, Biology and Life Sciences, Physics and Astronomy, COCHLEAR NEURAL MEMBRANE, NERVE-FIBERS, STIMULATION, CURRENTS, EXCITABILITY, NODE, axon modeling, electromagnetic exposure, intermediate frequencies, membrane channel dynamics, safety guidelines and standards |
| الوصف: | Occupational exposure limit values (ELVs) for body internal electric fields can be derived from thresholds for action potential generation. These thresholds can be calculated with electrostimulation models. The spatially extended nonlinear node model (SENN) is often used to determine such thresholds. Important parameters of these models are the membrane channel dynamics describing the ionic transmembrane currents as well as the temperature at which the models operate. This work compares action potential thresholds for five different membrane channel dynamics used with the SENN model. Furthermore, two more detailed double-cable models by Gaines et al. (MRG-Sensory and MRG-Motor) are also considered in this work. Thresholds calculated with the SENN model and the MRG models are compared for frequencies between 1 Hz and 100 kHz and temperatures at 22 degrees C and 37 degrees C. Results show that MRG thresholds are lower than SENN thresholds. Deriving alternative ELVs from these thresholds shows that the alternative ELVs can change significantly with different ion channel dynamics (up to a factor of 22). Using the double cable model could lead to approximately ten times lower alternative exposure limit values. On the contrary, using the SENN model with different membrane channel dynamics could also lead to higher alternative exposure limit values. Therefore, future exposure guidelines should take the influence of different electrostimulation models into account when deriving ELVs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://biblio.ugent.be/publication/01JH02SF2Z3E6Q9A4KESCHAP9V; http://doi.org/10.1002/bem.22529; https://biblio.ugent.be/publication/01JH02SF2Z3E6Q9A4KESCHAP9V/file/01JH02Z5FNTS2QZMQ224961FH0 |
| DOI: | 10.1002/bem.22529 |
| الاتاحة: | https://biblio.ugent.be/publication/01JH02SF2Z3E6Q9A4KESCHAP9V http://hdl.handle.net/1854/LU-01JH02SF2Z3E6Q9A4KESCHAP9V https://doi.org/10.1002/bem.22529 https://biblio.ugent.be/publication/01JH02SF2Z3E6Q9A4KESCHAP9V/file/01JH02Z5FNTS2QZMQ224961FH0 |
| Rights: | Creative Commons Attribution-NonCommercial 4.0 International Public License (CC BY-NC 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.950F1B4D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/bem.22529 |
|---|