Academic Journal
Retrospective case-series analysis of haematological malignancies in goldmining areas of South Africa
| العنوان: | Retrospective case-series analysis of haematological malignancies in goldmining areas of South Africa |
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| المؤلفون: | Inamasu, T, Patel, M, Espina, C, Pentz, A, Joffe, M, Winde, F, Schüz, J |
| المصدر: | South African Medical Journal; Vol 108, No 10 (2018); 858-864 ; 2078-5135 ; 0256-9574 |
| بيانات النشر: | South African Medical Association |
| سنة النشر: | 2018 |
| المجموعة: | South African Medical Journal (SAMJ) |
| مصطلحات موضوعية: | Haematological malignancies, Leukaemia, Lymphoma, Uranium, Mining, Goldmining, South Africa |
| الوصف: | Background. South Africa (SA)’s high levels of environmental contamination of mine tailings from uranium and its decay products, coupled with remarkably short distances between mine tailings and residential areas, raise concern about whether there is an association between environmental uranium exposure and risk of cancer, including haematological malignancies.Objectives. We reviewed information on cases from the central hospital offering cancer diagnostics and treatment in a major mining area of SA to describe their basic clinical and demographic characteristics, as part of assessing whether a cancer epidemiological study in this area would be feasible.Methods. Basic clinical, demographic and residential information on patients with haematological malignancy diagnosed between 2004 and 2013 was collected retrospectively from the patient files at Chris Hani Baragwanath Academic Hospital in Soweto, Johannesburg.Results. In total, 1 880 patients aged 18 - 94 years were identified. Referral from distant provinces was not uncommon, but >80% lived within 50 km of the hospital. Non-Hodgkin’s lymphoma accounted for 44% of the haematological malignancies, followed by leukaemia with 26%. HIV status was known for 93% of the patients, of whom 47% were HIV-positive.Conclusions. Caution is required when interpreting spatial distributions of patients, given inaccuracies in residential addresses and referral patterns to the hospital, and with HIV and other infections probable important confounders. Our study therefore shows that active case recruitment is required for accurate assessment of residential information. However, some findings on spatial distributions in the study warrant the continuation of efforts to develop a study protocol to investigate the possible link between uranium exposure in mining areas and haematological malignancies in residents. Disproportionately high incidence rates of haematological malignancies observed in specific districts would be relevant for further investigation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://samj.org.za/index.php/samj/article/view/12433/8638; http://samj.org.za/index.php/samj/article/view/12433 |
| DOI: | 10.7196/SAMJ.2018.v108i10.13175 |
| الاتاحة: | http://samj.org.za/index.php/samj/article/view/12433 https://doi.org/10.7196/SAMJ.2018.v108i10.13175 |
| Rights: | Copyright of published material remains in the Authors’ name. This allows authors to use their work for their own non-commercial purposes without seeking permission from the Publisher, subject to properly acknowledging the Journal as the original place of publication. Authors are free to copy, print and distribute their articles, in full or in part, for teaching activities, and to deposit or include their work in their own personal or institutional database or on-line website. Authors are requested to inform the Journal/Publishers of their desire/intention to include their work in a thesis or dissertation or to republish their work in any derivative form (but not for commercial use). Material submitted for publication in the SAMJ is accepted provided it has not been published or submitted for publication elsewhere. Please inform the editorial team if the main findings of your paper have been presented at a conference and published in abstract form, to avoid copyright infringement. |
| رقم الانضمام: | edsbas.9504CCF5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7196/SAMJ.2018.v108i10.13175 |
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