التفاصيل البيبلوغرافية
| العنوان: |
Concept of informational tool for MAFLD and COVID-19 severity interplay assessment |
| المؤلفون: |
Secrieru, I.P., Секриеру, Ю., Ţurcan, S.I., Turcan, S., Guţuleac, E.N., Гуцуляк, Е., Popcova, O.V., Попкова, О.В. |
| المصدر: |
Mathematics and Information Technologies: Research and Education |
| سنة النشر: |
2021 |
| الوصف: |
The earliest evidence suggested that obese patients, who often present Metabolic Associated Fatty Liver Disease MAFLD, are even more vulnerable at severe presentation of COVID-19. On the one hand, the ereg;ect of compromised liver function, as a result of MAFLD, on the severity of COVID-19 illness [1] has not been well studied yet. We aim to systematize the info and data of patients with fatty liver and evaluate the severity of COVID-19 in this cohort. On the other hand, most likely, these patients will receive drugs necessary for the treatment of acute respiratorynbsp;syndrome, antiviral agents and other drugs to treat systemic indeg;ammation, combat bacterial and fungal superinfections. Among these pharmaceuticals can produce some drug-induced liver injury DILI [2]. The mechanisms of DILI are not always understood. There is a clear need for a deeper understanding of interplay between MAFLD and severity of COVID-19. For more reliable and accurate results, we plan to create a partnership and combine the ereg;orts of medical experts and the specialists in the macr;eld of medical informatics. The overall research objective is to elucidate relationship between fatty liver and COVID-19 by creating a data warehouse of MAFLD cases, based on a single ontology protocol, and to provide intelligent information tool for quantifying and assessing the reciprocation of compromised liver function as a result of MAFLD and the severity of COVID-19 illness, and vice versa, COVID19 treatment and MAFLD progression, using our existing experience [3]. Relevance of the assumed overall objective is enormous, as we have witnessed the wide spread of MAFLD, which predominantly areg;ect people of working age, having a signimacr;cant negative impact on social and economic development. COVID-19 pandemic only made things worse. The research for this paper have been supported by the COST Action CA17112 \Prospective European Drug-Induced Liver Injury Networkquot; and the project 20.80009.5007.22 \Intelligent information systems for solving ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://ibn.idsi.md/vizualizare_articol/134354 |
| الاتاحة: |
https://ibn.idsi.md/vizualizare_articol/134354 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.94DFB358 |
| قاعدة البيانات: |
BASE |