Academic Journal

Evaluating the Patterns of FAPI Uptake in the Shoulder Joint: a Preliminary Study Comparing with FDG Uptake in Oncological Studies

التفاصيل البيبلوغرافية
العنوان: Evaluating the Patterns of FAPI Uptake in the Shoulder Joint: a Preliminary Study Comparing with FDG Uptake in Oncological Studies
المؤلفون: Matsusaka, Yohji, Werner, Rudolf A., Serfling, Sebastian E., Buck, Andreas K., Kosmala, Aleksander, Sasaki, Takanori, Weich, Alexander, Higuchi, Takahiro
المساهمون: Deutsche Forschungsgemeinschaft, Foundation for Promotion of Material Science and Technology of Japan, Universitätsklinikum Würzburg
المصدر: Molecular Imaging and Biology ; volume 26, issue 2, page 294-300 ; ISSN 1536-1632 1860-2002
بيانات النشر: Springer Science and Business Media LLC
سنة النشر: 2024
الوصف: Background Fibroblast activation protein inhibitor (FAPI) targeting PET has been introduced as a novel molecular imaging modality for visualizing cancer-associated fibroblasts. There have also been reports suggesting incidental findings of localized accumulation in the shoulder joints. However, further characterization in a larger patient cohort is still lacking. Methods 77 consecutive patients (28 females; mean age, 63.1 ± 11.6) who underwent Ga-68 FAPI-04 PET/CT for diagnosis of solid tumors were included. The incidence and localization of tracer uptake in shoulder joints were investigated and compared with available F-18 FDG scans serving as reference. Results Ga-68 FAPI-04 uptake was evaluated in 77 patients (154 shoulder joints), of whom 54 subjects (108 shoulder joints) also had available F-18 FDG scans for head-to-head comparison. On FAPI-targeted imaging, 67/154 shoulders (43.5%) demonstrated increased radiotracer accumulation in target lesions, which were distributed as follows: acromioclavicular (AC) joints in 25/67 (37.3%), followed by glenohumeral and subacromial (GH + SA) joints in 23/67 (34.3%), or both (AC and GH + SA joints) in the remaining 19/67 (28.4%). Ga-68 FAPI-04 correlated with quantified F-18 FDG uptake (r = 0.69, p < 0.0001). Relative to the latter radiotracer, however, in-vivo FAP expression in the shoulders was significantly increased (Ga-68 FAPI-04, 4.7 ± 3.2 vs F-18 FDG, 3.6 ± 1.3, p < 0.001). Conclusion Our study revealed focal accumulation of Ga-68 FAPI-04 in the shoulders, particularly in the AC joints, with higher uptake compared to the inflammatory-directed PET radiotracer F-18 FDG in oncological studies. As a result, further trials are warranted to investigate the potential of FAPI-directed molecular imaging in identifying chronic remodeling in shoulder joints. This could have implications for initiating anti-FAP targeted photodynamic therapy based on PET signal strength.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1007/s11307-023-01893-8
DOI: 10.1007/s11307-023-01893-8.pdf
DOI: 10.1007/s11307-023-01893-8/fulltext.html
الاتاحة: http://dx.doi.org/10.1007/s11307-023-01893-8
https://link.springer.com/content/pdf/10.1007/s11307-023-01893-8.pdf
https://link.springer.com/article/10.1007/s11307-023-01893-8/fulltext.html
Rights: https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0
رقم الانضمام: edsbas.94D9D9B6
قاعدة البيانات: BASE
الوصف
DOI:10.1007/s11307-023-01893-8