Academic Journal
Baseline neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) correlate with advanced stages in cutaneous squamous cell carcinoma
| العنوان: | Baseline neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) correlate with advanced stages in cutaneous squamous cell carcinoma |
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| المؤلفون: | Di Raimondo C., Caposiena Caro R. D., Spallone D., Silvaggio D., Lombardo P., Del Duca E., Campione E., Spallone G., Bianchi L. |
| المساهمون: | Di Raimondo, C., Caposiena Caro, R. D., Spallone, D., Silvaggio, D., Lombardo, P., Del Duca, E., Campione, E., Spallone, G., Bianchi, L. |
| بيانات النشر: | John Wiley and Sons Inc |
| سنة النشر: | 2022 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | patients treated upfront, lymphocyte ratio, neutrophil, cancer, marker, hallmark, impact, risk |
| الوصف: | Background: The neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) at diagnosis have been shown to correlate with advanced disease and to be prognostic factors in many tumors. However, their role as a prognostic factor for cutaneous squamous cell carcinoma (cSCC) has not yet been studied. Objective: Therefore, the aim of our study was to evaluate the correlation of NLR and RDW with stages of disease in patients with cSCC in order to define whether or not higher values of these two markers correlate with a more aggressive disease. Methods: We retrospectively analyzed the NLR and RDW in a total of 51 newly diagnosed cSCC patients. NLR and RDW were calculated using data obtained from the complete blood count (CBC). Results: Median NLR among patients with the non-advanced disease (insitu and stage I) was 2.2, whereas median NLR for patients with advanced disease was 4.87. Median RDW among patients with early stage disease was 13.7%, while median RDW in patients with advanced disease was 15.81%. Statistical analysis showed positive associations of advanced cSCC stages with NLR or RDW higher than 3.07 or 14.5%, respectively. Conclusions: Therefore, our analysis demonstrated how both NLR and RDW represent cheap and easily available factors that could be used as markers for advanced cSCC. They could help to identify patients with advanced stages disease that requires a strict follow-up. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34212366; info:eu-repo/semantics/altIdentifier/wos/WOS:000668879100001; volume:61; issue:2; firstpage:175; lastpage:179; numberofpages:5; journal:INTERNATIONAL JOURNAL OF DERMATOLOGY; https://hdl.handle.net/11573/1712022; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85109005348 |
| DOI: | 10.1111/ijd.15755 |
| الاتاحة: | https://hdl.handle.net/11573/1712022 https://doi.org/10.1111/ijd.15755 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.94D8110D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/ijd.15755 |
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