Academic Journal
Emergence of oxygen‐ and pyridoxal phosphate‐dependent reactions
| العنوان: | Emergence of oxygen‐ and pyridoxal phosphate‐dependent reactions |
|---|---|
| المؤلفون: | Hoffarth, Elesha R., Rothchild, Kristina W., Ryan, Katherine S. |
| المساهمون: | Michael Smith Foundation for Health Research, Natural Sciences and Engineering Research Council of Canada, Canadian Institutes of Health Research |
| المصدر: | The FEBS Journal ; volume 287, issue 7, page 1403-1428 ; ISSN 1742-464X 1742-4658 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Pyridoxal 5′‐phosphate (PLP) is an organic cofactor employed by ~ 4% of enzymes. The structure of the PLP cofactor allows for the stabilization of carbanions through resonance. A small number of PLP‐dependent enzymes employ molecular oxygen as a cosubstrate. Here, we review the biological roles and possible mechanisms of these enzymes, and we observe that these enzymes are found in multiple protein families, suggesting that reaction with oxygen might have emerged de novo in several protein families and thus could be directed to emerge again through laboratory evolution experiments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/febs.15277 |
| الاتاحة: | http://dx.doi.org/10.1111/febs.15277 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ffebs.15277 https://onlinelibrary.wiley.com/doi/pdf/10.1111/febs.15277 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/febs.15277 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.15277 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.94B02106 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/febs.15277 |
|---|