Academic Journal
Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway
| العنوان: | Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway |
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| المؤلفون: | Wu, Yi-Bo, Li, Shen-Yi, Liu, Jin-Yan, Xue, Jia-Jia, Xu, Jin-Fu, Chen, Ting, Cao, Tian-Yue, Zhou, Hui, Wu, Tian-Tian, Dong, Chun-Lin, Qian, Wei-Feng, Qiao, Long-Wei, Hou, Shun-Yu, Wang, Ting, Shen, Cong |
| المصدر: | Cell Death & Disease ; volume 14, issue 10 ; ISSN 2041-4889 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | As a common malignant tumor among women, ovarian cancer poses a serious threat to their health. This study demonstrates that long non-coding RNA NRSN2-AS1 is over-expressed in ovarian cancer tissues using patient sample and tissue microarrays. In addition, NRSN2-AS1 is shown to promote ovarian cancer cell proliferation and metastasis both in vitro and in vivo. Mechanistically, NRSN2-AS1 stabilizes protein tyrosine kinase 2 (PTK2) to activate the β-catenin pathway via repressing MG-53-mediated ubiquitinated degradation of PTK2, thereby facilitating ovarian cancer progression. Rescue experiments verify the function of the NRSN2-AS1/PTK2/β-catenin axis and the effects of MG53 on this axis in ovarian cancer cells. In conclusion, this study demonstrates the key role of the NRSN2-AS1/PTK2/β-catenin axis for the first time and explores its potential clinical applications in ovarian cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41419-023-06214-z |
| الاتاحة: | http://dx.doi.org/10.1038/s41419-023-06214-z https://www.nature.com/articles/s41419-023-06214-z.pdf https://www.nature.com/articles/s41419-023-06214-z |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.948213EB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41419-023-06214-z |
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