Academic Journal
The Roles of Radiotherapy and Chemotherapy in the Era of Multimodal Treatment for Early-Stage Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma.
| العنوان: | The Roles of Radiotherapy and Chemotherapy in the Era of Multimodal Treatment for Early-Stage Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma. |
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| المساهمون: | College of Medicine, Dept. of Internal Medicine, Tae Hyung Kim, Jin Seok Kim, Yang-Gun Suh, Jaeho Cho, Woo-Ick Yang, Chang-Ok Suh, Kim, Jin Seok, Suh, Chang Ok, Yang, Woo Ick, Cho, Jae Ho |
| بيانات النشر: | Yonsei University Korea (South) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Aged, Carcinoma in Situ/mortality, Carcinoma in Situ/pathology, Carcinoma in Situ/therapy, Disease Progression, Disease-Free Survival, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/mortality, Local/pathology, Prognosis, Proportional Hazards Models, Republic of Korea, Retrospective Studies, Risk, Urinary Bladder Neoplasms/mortality, Urinary Bladder Neoplasms/pathology, Urinary Bladder Neoplasms/therapy, Urinary bladder neoplasm, recurrence |
| الوصف: | PURPOSE: To evaluate radiotherapy (RT) and chemotherapy (CT) treatments of early-stage extranodal natural killer/T-cell lymphoma (ENKTL). MATERIALS AND METHODS: Fifty-five patients with stage I or II ENKTL [n=39 (71%) and 16 (29%) patients, respectively] who were treated with RT between 1999 and 2013 were analyzed retrospectively. The median age was 54 years (range, 24-81). Patients were grouped by treatment modality as RT alone [n=19 (35%)], upfront CT plus RT [CT+RT, n=16 (29%)], and concurrent chemoradiotherapy [CCRT, n=20 (36%)]. The median RT dose was 48 Gy. Patient characteristics between each treatment group were well balanced. Patterns of failure and survival were analyzed. RESULTS: The overall response rate after RT was 94.6%. Ten patients experienced distant failure, and seven experienced local failure comprising five in-field and two out-field failures. The local and distant failure rates in the RT-alone group were the same (16%). In the CT+RT group, the most common failure sites were local (19%). In the CCRT group, the most common failures were distant (25%). At a median follow-up of 56 months (range, 1-178 months), the 5-year overall survival (OS) and progression-free survival rates were 66% and 54%, respectively. The 5-year OS rate for the RT-alone and CT+RT groups were 76% and 69%, respectively, and the 2-year OS rate for the CCRT group was 62% (p=0.388). CONCLUSION: In the era of multimodal treatment for ENKTL, RT alone using advanced techniques should be considered for local disease control, whereas maintenance CT regimens should be considered for distant disease control. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 846~854 |
| اللغة: | English |
| تدمد: | 0513-5796 1976-2437 |
| Relation: | YONSEI MEDICAL JOURNAL; J02813; OAK-2016-03041; https://ir.ymlib.yonsei.ac.kr/handle/22282913/147059; T201602035; YONSEI MEDICAL JOURNAL, Vol.57(4) : 846-854, 2016 |
| DOI: | 10.3349/ymj.2016.57.4.846 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147059 https://doi.org/10.3349/ymj.2016.57.4.846 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ |
| رقم الانضمام: | edsbas.9469FFB0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 05135796 19762437 |
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| DOI: | 10.3349/ymj.2016.57.4.846 |