Academic Journal
Haemodynamic effects of pimobendan during general anaesthesia in healthy senior dogs a prospective, randomised, triple-blinded, placebo-controlled clinical study
| العنوان: | Haemodynamic effects of pimobendan during general anaesthesia in healthy senior dogs a prospective, randomised, triple-blinded, placebo-controlled clinical study |
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| المؤلفون: | Sández Cordero, Ignacio., Redondo García, José Ignacio., Donati, Pablo., Gómez García, José. |
| المساهمون: | UCH. Departamento de Medicina y Cirugía Animal, Producción Científica UCH 2023 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Universidad San Pablo CEU Madrid: Repositorio Institucional |
| مصطلحات موضوعية: | Cardiotonic agents in Veterinary Medicine, Cardiotónicos en veterinaria, Medicamentos veterinarios, Veterinary drugs, Hemodynamics, Veterinary anesthesia, Pimobendan - Uso terapéutico, Pimobendan - Therapeutic use, Hemodinámica, Anestesia veterinaria |
| الوصف: | Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2076-2615/13/13/2110 ; Este artículo de investigación pertenece al número especial "Pharmacokinetics and Pharmacodynamics in Animal Anesthesiology". ; Pimobendan is an inotropic and vasodilator drug with no sympathomimetic effects. This study aimed to evaluate the haemodynamic effects of pimobendan during anaesthesia in healthy senior dogs. A prospective, randomised, triple-blinded, placebo-controlled clinical study was conducted. Thirty-three dogs (median [range]: 9 [7, 12] years) were anaesthetised for surgical procedures. The dogs were randomly allocated into two groups: eighteen dogs received intravenous pimobendan at a dose of 0.15 mg/kg (PIMOBENDAN), and fifteen dogs received intravenous saline solutions at a dose of 0.2 mL/kg (PLACEBO). Data were recorded before, 1 min, 10 min, and 20 min after injection. Velocity-time integral (VTI), peak-velocity (PV), and mean-acceleration (MA) were measured using an oesophageal Doppler monitor (ODM). Heart rate and mean arterial pressure were also registered. The data were analysed using a two-way ANOVA for trimmed means. Statistical differences were considered if p < 0.05. Twenty minutes after injection, the VTI (13.0 cm [10.4, 22.3]), PV (95.0 [83.0, 160]m/s), andMA (12.6 [9.40, 17.0]m/s2)were significantly higher in the PIMOBENDAN group compared to the PLACEBO group (VTI: 10.5 [6.50, 17.4] cm, PV: 80.0 [62.0, 103] m/s and MA: 10.2 [7.00, 16.0] ms2). No significant differences were observed in the rest of the variables. Using pimobendan during anaesthesia increases VTI, PV, and MA, as measured by an ODM. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Spanish; Castilian English |
| Relation: | Animals, vol. 13, i. 13 (26 jun. 2023); Sández, I., Redondo, J.I., Donati, P.A. & Gómez, J. (2023). Haemodynamic effects of pimobendan during general anaesthesia in healthy senior dogs: a prospective, randomised, triple-blinded, placebo-controlled clinical study. Animals, vol. 13, i. 13 (26 jun.), art. 2110. DOI: http://dx.doi.org/10.3390/ani13132110; 2076-2615 (Electrónico); http://hdl.handle.net/10637/14496; https://doi.org/10.3390/ani13132110 |
| DOI: | 10.3390/ani13132110 |
| الاتاحة: | http://hdl.handle.net/10637/14496 https://doi.org/10.3390/ani13132110 |
| Rights: | http://creativecommons.org/licenses/by/4.0/deed.es |
| رقم الانضمام: | edsbas.9458AD73 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ani13132110 |
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