Academic Journal
Schottky Barrier-Based Built-In Electric Field for Enhanced Tumor Photodynamic Therapy
| العنوان: | Schottky Barrier-Based Built-In Electric Field for Enhanced Tumor Photodynamic Therapy |
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| المؤلفون: | Yun Sun, Hongyu Wang, Yuhan Yang, Shunhao Wang, Bolong Xu, Zhijun Huang, Huiyu Liu |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Medicine, Biotechnology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, vitro cellular level, singlet oxygen increased, reactive oxygen species, provides new ideas, photothermal conversion efficiency, pd also enhanced, inhibit tumor growth, infrared laser irradiation, improving photodynamic performance, develop efficient pss, 9 %, respectively, enhanced carrier dynamics, allowing effective production, 3 , effective ps, carrier lifetime, 3 times, urgent need, trigger apoptosis, study reveals, signal intensity, schottky barrier, ps ) |
| الوصف: | Photodynamic therapy’s antitumor efficacy is hindered by the inefficient generation of reactive oxygen species (ROS) due to the photogenerated electron–hole pairs recombination of photosensitizers (PS). Therefore, there is an urgent need to develop efficient PSs with enhanced carrier dynamics. Herein, we designed Schottky junctions composed of cobalt tetroxide and palladium nanocubes (Co 3 O 4 @Pd) with a built-in electric field as effective PS. The built-in electric field enhanced photogenerated charge separation and migration, resulting in the generation of abundant electron–hole pairs and allowing effective production of ROS. Thanks to the built-in electric field, the photocurrent intensity and carrier lifetime of Co 3 O 4 @Pd were approximately 2 and 3 times those of Co 3 O 4 , respectively. Besides, the signal intensity of hydroxyl radical and singlet oxygen increased to 253.4% and 135.9%, respectively. Moreover, the localized surface plasmon resonance effect of Pd also enhanced the photothermal conversion efficiency of Co 3 O 4 @Pd to 40.50%. In vitro cellular level and in vivo xenograft model evaluations demonstrated that Co 3 O 4 @Pd could generate large amounts of ROS, trigger apoptosis, and inhibit tumor growth under near-infrared laser irradiation. Generally, this study reveals the contribution of the built-in electric field to improving photodynamic performance and provides new ideas for designing efficient inorganic PSs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Schottky_Barrier-Based_Built-In_Electric_Field_for_Enhanced_Tumor_Photodynamic_Therapy/25305916 |
| DOI: | 10.1021/acsami.4c00018.s001 |
| الاتاحة: | https://doi.org/10.1021/acsami.4c00018.s001 https://figshare.com/articles/journal_contribution/Schottky_Barrier-Based_Built-In_Electric_Field_for_Enhanced_Tumor_Photodynamic_Therapy/25305916 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.941EA327 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsami.4c00018.s001 |
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