Academic Journal
Drug survival of biologic agents in patients with psoriatic arthritis from a medical center in southern Taiwan
| العنوان: | Drug survival of biologic agents in patients with psoriatic arthritis from a medical center in southern Taiwan |
|---|---|
| المؤلفون: | Yu, Sebastian, Tsao, Yu-Hsiang, Tu, Hung-Pin, Lan, Cheng-Che E. |
| المصدر: | Dermatologica Sinica ; volume 40, issue 1, page 20-27 ; ISSN 1027-8117 |
| بيانات النشر: | Medknow |
| سنة النشر: | 2022 |
| الوصف: | Background: Psoriasis is a chronic inflammatory disease involving the skin and/or joints. Till 2016, there were five biologic agents for psoriatic arthritis treatment in Taiwan: etanercept, adalimumab, golimumab, ustekinumab, and secukinumab. Although European guidelines recommend tumor necrosis factor-α (TNF-α) inhibitors as the first-line biologic agents for axial disease of psoriatic arthritis, the drug survival of biologic agents in Asian populations remains unclear. Objectives: We investigated 5-year drug survival of biologic agents in patients with psoriatic arthritis. Methods: We used Kaohsiung Medical University Hospital Research Database to evaluate real-world 5-year drug survival of biologic agents for psoriatic arthritis in a medical center from southern Taiwan. Results: The 5-year drug survival rates of ustekinumab, etanercept, and adalimumab were significantly different. Ustekinumab and etanercept showed higher 5-year survival rates for psoriatic disease than adalimumab. Golimumab and secukinumab had a short follow-up time to obtain a conclusive 5-year survival rate. Conclusion: Considering that TNF-α inhibitors are often the first-line biologic agents for psoriatic arthritis in guidelines in western countries, the finding that ustekinumab is superior to TNF-α inhibitor adalimumab in terms of 5-year survival for psoriatic disease may imply that the therapeutic response of biologic agents may differ between different ethnic groups. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.4103/ds.ds_8_22 |
| الاتاحة: | https://doi.org/10.4103/ds.ds_8_22 https://journals.lww.com/10.4103/ds.ds_8_22 |
| رقم الانضمام: | edsbas.93FDFA7D |
| قاعدة البيانات: | BASE |
| DOI: | 10.4103/ds.ds_8_22 |
|---|