التفاصيل البيبلوغرافية
| العنوان: |
The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma |
| المؤلفون: |
Sascha Marx, Yong Xiao, Marcel Baschin, Maximilian Splittstöhser, Robert Altmann, Eileen Moritz, Gabriele Jedlitschky, Sandra Bien-Möller, Henry W.S. Schroeder, Bernhard H. Rauch |
| المصدر: |
Cancers; Volume 11; Issue 4; Pages: 569 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
glioblastoma multiforme, platelet, immune cell interaction, sphingosine-1-phosphate |
| الوصف: |
The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the last decade. Malignant gliomas differ tremendously from malignancies outside the central nervous system because they virtually never form distant metastases. This review summarizes the current understanding of the platelet–immune cell communication and its potential role in glioma resistance and progression. Particularly, we focus on platelet-derived proinflammatory modulators, such as sphingosine-1-phosphate (S1P). The multifaceted interaction with immune cells puts the platelet into an interesting perspective regarding the recent advances in immunotherapeutic approaches in malignant glioma. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dx.doi.org/10.3390/cancers11040569 |
| DOI: |
10.3390/cancers11040569 |
| الاتاحة: |
https://doi.org/10.3390/cancers11040569 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.93EE8F56 |
| قاعدة البيانات: |
BASE |