Academic Journal
A gut microbiome signature for HIV and metabolic dysfunction-associated steatotic liver disease
| العنوان: | A gut microbiome signature for HIV and metabolic dysfunction-associated steatotic liver disease |
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| المؤلفون: | Martínez Sanz, Javier, Talavera Rodríguez, Alba, Díaz Álvarez, Jorge, Rosas Cancio-Suárez, Marta, Rodríguez Gómez, Juan Miguel, Alba Rubio, Claudio, Montes, María Luisa, Martín Mateos, Rosa, Burgos Santamaría, Diego, Moreno, Santiago, Serrano Villar, Sergio, Sánchez Conde, Matilde |
| بيانات النشر: | Frontiers |
| سنة النشر: | 2023 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 612.017, HIV, MASLD, NAFLD, Gut microbiome, Microbiome, Veterinaria, 3109 Ciencias Veterinarias |
| الوصف: | Author contributions: JM: Formal Analysis, Investigation, Software, Writing – original draft. AT: Formal Analysis, Investigation, Writing – original draft. JD: Supervision, Writing – review & editing. MC: Writing – review & editing. JR: Formal Analysis, Methodology, Software, Writing – review & editing. CA: Investigation, Writing – review & editing. MM: Writing – review & editing. RM: Writing – review & editing. DB: Writing – review & editing. SM: Writing – review & editing. SS: Conceptualization, Methodology, Validation, Writing – review & editing. MS: Conceptualization, Formal Analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing. ; Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), has emerged as an increasingly recognized problem among people living with HIV (PLWH). The gut-liver axis is considered to be strongly implicated in the pathogenesis of MASLD. We aimed to characterize the gut microbiota composition in PLWH and MASLD and compare it with that of two control groups: PLWH without MASLD and individuals with MASLD without HIV infection. Methods: We collected clinical data and stool samples from participants. Bacterial 16S rRNA genes were amplified, sequenced, and clustered into operational taxonomic unit. Alpha diversity was studied by Shannon and Simpson indexes. To study how different the gut microbiota composition is between the different groups, beta diversity estimation was evaluated by principal coordinate analysis (PCoA) using Bray-Curtis dissimilarity. To further analyze differences in microbiome composition we performed a linear discriminant analysis (LDA) effect size (LEfSe). Results: We included 30 HIV+MASLD+, 30 HIV+MASLD- and 20 HIV-MASLD+ participants. Major butyrate producers, including Faecalibacterium, Ruminococcus, and Lachnospira dominated the microbiota in all three groups. Shannon’s and Simpson’s diversity metrics were higher among MASLD+ individuals ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| Relation: | info:eu-repo/grantAgreement/MCIU/PEICTI2013-2016/PI17-01717; https://hdl.handle.net/20.500.14352/103711; Martínez-Sanz J, Talavera-Rodríguez A, Díaz-Álvarez J, Rosas Cancio-Suárez M, Rodríguez JM, Alba C, Montes ML, Martín-Mateos R, Burgos-Santamaría D, Moreno S, Serrano-Villar S and Sánchez Conde M (2023) A gut microbiome signature for HIV and metabolic dysfunction-associated steatotic liver disease. Front. Immunol. 14:1297378. doi:10.3389/fimmu.2023.1297378; https://doi.org/10.3389/fimmu.2023.1297378 |
| DOI: | 10.3389/fimmu.2023.1297378 |
| الاتاحة: | https://hdl.handle.net/20.500.14352/103711 https://doi.org/10.3389/fimmu.2023.1297378 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; open access |
| رقم الانضمام: | edsbas.93DB0EA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2023.1297378 |