Academic Journal
Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro
| العنوان: | Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro |
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| المؤلفون: | Odds, F. C., Bossche, H. Vanden |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2000 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Brief reports |
| الوصف: | Microbroth dilution tests in vitro showed the same IC 50 values for itraconazole and hydroxy-itraconazole, within a mode ± one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10–15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than hydroxy-itraconazole. Replicate tests with bioassay marker strains of Candida kefyr and Candida albicans showed no susceptibility variations outside the mode ± one dilution range. We conclude that few fungi differ substantially in their susceptibility to itraconazole and hydroxy-itraconazole. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://jac.oxfordjournals.org/cgi/content/short/45/3/371; http://dx.doi.org/10.1093/jac/45.3.371 |
| DOI: | 10.1093/jac/45.3.371 |
| الاتاحة: | http://jac.oxfordjournals.org/cgi/content/short/45/3/371 https://doi.org/10.1093/jac/45.3.371 |
| Rights: | Copyright (C) 2000, The British Society for Antimicrobial Chemotherapy |
| رقم الانضمام: | edsbas.93C461AB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jac/45.3.371 |
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